Expression of bcl-2 protein in gastric carcinoma and its significance

doi:10.3748/wjg.v4.i3.228

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 15, 1998; 4(3): 228-230
Published online Jun 15, 1998. doi: 10.3748/wjg.v4.i3.228

Expression of bcl-2 protein in gastric carcinoma and its significance

Hai-Feng Liu, Wei-Wen Liu, Dian-Chun Fang, Rong-Pu Men

Hai-Feng Liu, Wei-Wen Liu, Dian-Chun Fang, Rong-Pu Men, Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China

Hai-Feng Liu, physician-in-charge, having 16 papers published.

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Hai-Feng Liu, Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China

Telephone: +86-23-65318301 ext 73049

Received: January 20, 1998
Revised: March 26, 1998
Accepted: May 5, 1998
Published online: June 15, 1998

Abstract

AIM: To further study the role of bcl-2 protein expression in gastric carcinogenesis and tumor progression.

METHODS: Using immunohistochemical staining, the bcl-2 protein expression in 50 cases of gastric carcinoma and its relation to clinical status and pathomorphological parameters were observed.

RESULTS: Forty-one (82%) cases were positive for bcl-2 protein staining which was located in the cytoplasm and nuclear membrane of tumor cells. The rate of bcl-2 protein expression was not correlated with the patient, sex, tumor size, lymph node status or clinical stages (P > 0.05). It was strongly associated with intestinal-type tumors and poorly differentiated tumors (P < 0.05 and P < 0.01).

CONCLUSION: Aberrant bcl-2 protein expression appears to be specifically associated with development of intestinal-type gastric carcinoma, bcl-2 protein expression might play an important role in the early development/promotion and phenotypic differentiation of gastric carcinomas, but not in tumor progression.

Keywords: stomach neoplasms/pathology; bcl-2 protein; gene expression; immunohistochemical; lymphatic metastasis