Overexpression of P53 and its risk factors in esophageal cancer in urban areas of Xi&rsquo;an

doi:10.3748/wjg.v4.i1.57

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 4, Issue 1

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (2910)

All Articles published online

The chart showing PDF series, HTML series, Tables (1-3) series.

Item

Count

PDF

284

HTML

2240

Tables (1-3)

372

Sum=2896

Feb 15, 1998 (publication date) through Feb 13, 2026

Times Cited of This Article

Times Cited (15)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Original Article

World J Gastroenterol. Feb 15, 1998; 4(1): 57-60
Published online Feb 15, 1998. doi: 10.3748/wjg.v4.i1.57

Overexpression of P53 and its risk factors in esophageal cancer in urban areas of Xi’an

Gui-Bin Qiao, Cheng-Long Han, Ren-Chao Jiang, Chang-Sheng Sun, Yan Wang, Yun-Jie Wang

Gui-Bin Qiao, Ren-Chao Jiang, Department of Thoracic and Cardiovascular Surgery, Guangzhou General Hospital of Guangzhou Military Command, PLA, Guangzhou 510010, Guangdong Province, China

Cheng-Long Han, Laboratory of Cellular Oncology, National Cancer Institute, USA

Chang-Sheng Sun, Yan Wang, Yun-Jie Wang, Department of Epidemiology, the Fourth Military Medical University, Xi’an 710000, Shaanxi Province, China

Gui-Bin Qiao, male, born on 1969-07-20 in Taiyuan, Shaanxi Province, graduated from the Fourth Military Medical University, as a postgraduate in 1996, specialized in research and treatment of thoracic diseases, having more than 10 papers and 3 books published.

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Gui-Bin Qiao, Department of Thoracic and Cardiovascular Surgery, Guangzhou General Hospital of Guangzhou Military Command, PLA, Guangzhou 510010, Guangdong Province,China

Telephone: +86-20-86694772

Received: January 2, 1997
Revised: March 26, 1997
Accepted: April 20, 1997
Published online: February 15, 1998

Abstract

AIM: To investigate the risk factors of esophageal cancer (EC) in urban areas of Xi’an and to determine the association between overexpression of P53 and these risk factors.

METHODS: All cases (89) and controls (97) were permanent residents in urban areas of Xi’an, all cases of primary EC had been histologically confirmed, controls were inpatients with non-cancer and nonsmoking-related disease. Cancer tissues and tissues adjacent to the cancer of 65 cases and 24 available normal esophageal tissues of controls were detected for P53 overexpression by the immunohistochemical method.

RESULTS: The smoking and familial history of cancer were significantly associated with EC in Xi’an inhabitants. The laboratory assay indicated that P53 positive stain in EC was 50.0%(34/65)and 6.1%(4/65) in tissues adjacent to the cancer, but no positive stain was found in normal esophageal tissues of controls. The results showed that P53 overexpression in EC was closely related to smoking and cases with familial history of cancer.

CONCLUSION: Smoking and familial cancer history were important risk factors for EC,and the alteration of P53 gene may be due to smoking and inheritance factors.

Keywords: esophageal neoplasms; tumor suppressor gene; smoking; genes, p53; mutation; risk factors; immunohistochemistry