Liu JL, Wang CX, Wang HL. Advances in the management of cancer-related incomplete intestinal obstruction: Therapeutic strategies and emerging interventions. World J Gastroenterol 2026; 32(5): 115030 [DOI: 10.3748/wjg.v32.i5.115030]
Corresponding Author of This Article
Chun-Xi Wang, Department of Gastrointestinal Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. wangchunxi_2020@126.com
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Gastroenterology & Hepatology
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Editorial
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Feb 7, 2026 (publication date) through Jan 28, 2026
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Publication Name
World Journal of Gastroenterology
ISSN
1007-9327
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Liu JL, Wang CX, Wang HL. Advances in the management of cancer-related incomplete intestinal obstruction: Therapeutic strategies and emerging interventions. World J Gastroenterol 2026; 32(5): 115030 [DOI: 10.3748/wjg.v32.i5.115030]
World J Gastroenterol. Feb 7, 2026; 32(5): 115030 Published online Feb 7, 2026. doi: 10.3748/wjg.v32.i5.115030
Advances in the management of cancer-related incomplete intestinal obstruction: Therapeutic strategies and emerging interventions
Jia-Le Liu, Chun-Xi Wang, He-Lei Wang
Jia-Le Liu, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Chun-Xi Wang, He-Lei Wang, Department of Gastrointestinal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Co-corresponding authors: Chun-Xi Wang and He-Lei Wang.
Author contributions: Liu JL wrote the initial draft; Wang HL contributed to literature review; Wang CX contributed to the study design; Wang CX and Wang HL made equal contributions as co-corresponding authors. All authors approved the final version to be published.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chun-Xi Wang, Department of Gastrointestinal Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. wangchunxi_2020@126.com
Received: October 9, 2025 Revised: November 3, 2025 Accepted: November 26, 2025 Published online: February 7, 2026 Processing time: 115 Days and 0.3 Hours
Abstract
Cancer-related incomplete intestinal obstruction (CRIO) presents a significant challenge in patients with advanced malignancies, affecting quality of life and complicating treatment regimens. This editorial explores the multifaceted approaches to managing CRIO, emphasizing recent advancements in diagnostic techniques, pharmacological treatments, minimally invasive procedures, and surgical interventions. The pathophysiology of CRIO is complex, involving tumor invasion, fibrosis, and peritoneal dissemination, which result in partial bowel obstruction and impaired motility. Traditional management has focused on supportive care and palliative measures; however, new interventions, such as endoscopic stenting and laparoscopic surgery, have demonstrated improved outcomes with fewer complications. In addition, the integration of systemic therapies like immunotherapy and targeted agents offers promising results in reducing tumor burden and alleviating obstruction. The editorial also discusses the critical role of nutritional support and fluid management in managing CRIO symptoms and improving patient recovery. Despite these advancements, the complexity of CRIO, with its varied causes and patient-specific factors, necessitates individualized, multidisciplinary care strategies. This editorial aims to provide an updated, comprehensive framework for clinicians managing CRIO, highlighting current practices and future directions for research and therapeutic development.
Core Tip: Cancer-related incomplete intestinal obstruction represents a multifactorial clinical challenge in patients with advanced malignancies, combining mechanical, inflammatory, and functional components. This editorial systematically summarizes recent progress in the diagnosis and management of cancer-related incomplete intestinal obstruction, including advances in imaging, pharmacological therapy, nutritional optimization, minimally invasive intervention, and surgical strategies. It emphasizes the integration of multidisciplinary care and emerging targeted therapies, highlighting the shift toward individualized, patient-centered management aimed at improving prognosis and quality of life.
