Smirnova OV, Sinyakov AA, Kasparov EV. Letter to the editor: Pathogenetic factors in the development of metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(31): 122317 [DOI: 10.3748/wjg.122317]
Corresponding Author of This Article
Olga V Smirnova, Professor, Laboratory of Clinical Pathophysiology, Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”, Separate Subdivision Research Institute for Medical Problems of the North, Partizana Zheleznyaka Street 3G, Krasnoyarsk 660022, Russia. ovsmirnova71@mail.ru
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Pathology
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letter
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Smirnova OV, Sinyakov AA, Kasparov EV. Letter to the editor: Pathogenetic factors in the development of metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(31): 122317 [DOI: 10.3748/wjg.122317]
World J Gastroenterol. Aug 21, 2026; 32(31): 122317 Published online Aug 21, 2026. doi: 10.3748/wjg.122317
Letter to the editor: Pathogenetic factors in the development of metabolic dysfunction-associated steatotic liver disease
Olga V Smirnova, Aleksander A Sinyakov, Edward V Kasparov
Olga V Smirnova, Aleksander A Sinyakov, Laboratory of Clinical Pathophysiology, Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”, Separate Subdivision Research Institute for Medical Problems of the North, Krasnoyarsk 660022, Russia
Edward V Kasparov, Department of Administration, Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North, Krasnoyarsk 660022, Russia
Author contributions: Smirnova OV wrote the original draft; Sinyakov AA contributed to conceptualization, writing, reviewing and editing; Smirnova OV, Sinyakov AA and Kasparov EV participated in manuscript drafting; and all the authors have read and approved the final version of the manuscript.
AI contribution statement: AI tools (specifically DeepSeek) were used solely for linguistic refinement and formatting assistance. No AI tool was involved in the generation of research data, interpretation of results, or formulation of conclusions. All AI-generated outputs were critically reviewed and revised by the authors.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Olga V Smirnova, Professor, Laboratory of Clinical Pathophysiology, Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”, Separate Subdivision Research Institute for Medical Problems of the North, Partizana Zheleznyaka Street 3G, Krasnoyarsk 660022, Russia. ovsmirnova71@mail.ru
Received: April 16, 2026 Revised: June 5, 2026 Accepted: June 18, 2026 Published online: August 21, 2026 Processing time: 111 Days and 4.1 Hours
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) has currently become one of the most significant public health concerns. Recently, an increasing number of studies have indicated a close association between MASLD and not only liver diseases but also cardiovascular diseases. This is attributed to shared pathophysiological mechanisms, including insulin resistance, lipid metabolism disorders, systemic inflammation, and oxidative stress. The study by Mapouka et al, published in the World Journal of Gastroenterology, presents a meta-analysis of various outcomes in patients with MASLD and obesity compared to those with a normal body mass index. This study deserves particular attention, as it addresses a pressing issue in gastroenterology.
Core Tip: This article is dedicated to elucidating the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) in individuals with a normal body mass index (BMI). The problem of MASLD is examined in the study by Mapouka et al, published in the World Journal of Gastroenterology, in which the authors conduct a meta-analysis of data on outcomes of metabolic liver disorders and cardiovascular diseases in MASLD over the past 20 years in individuals with obesity and normal BMI. This study is notable for an extremely promising and strategically new objective.
