Chen B, Han H, Zhang XX, Chen JX, Fan X. Research progress in laparoscopic endoscopic cooperative surgery for early gastric cancer: A narrative review. World J Gastroenterol 2026; 32(30): 119614 [DOI: 10.3748/wjg.119614]
Corresponding Author of This Article
Ji-Xiang Chen, MD, Chief, Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangsu University, No. 438 Jiefang Road, Jingkou District, Zhenjiang 212000, Jiangsu Province, China. jsdxfsyycjx@163.com
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Medicine, Research & Experimental
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review-article
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Chen B, Han H, Zhang XX, Chen JX, Fan X. Research progress in laparoscopic endoscopic cooperative surgery for early gastric cancer: A narrative review. World J Gastroenterol 2026; 32(30): 119614 [DOI: 10.3748/wjg.119614]
World J Gastroenterol. Aug 14, 2026; 32(30): 119614 Published online Aug 14, 2026. doi: 10.3748/wjg.119614
Research progress in laparoscopic endoscopic cooperative surgery for early gastric cancer: A narrative review
Biao Chen, He Han, Xuan-Xuan Zhang, Ji-Xiang Chen, Xin Fan
Biao Chen, He Han, Xuan-Xuan Zhang, Ji-Xiang Chen, Xin Fan, Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang 212000, Jiangsu Province, China
Co-first authors: Biao Chen and He Han.
Co-corresponding authors: Ji-Xiang Chen and Xin Fan.
Author contributions: Chen B and Han H contributed equally to this work and are co-first authors; Fan X and Chen JX were responsible for the study design, revising and updating the initial draft of the manuscript, they contributed equally to this manuscript and are co-corresponding authors; Chen B, Han H, Zhang XX, Chen JX, and Fan X authored the initial draft; Chen B was responsible for using the software to draw and chart; all authors contributed to editing, and agreed to the published version of the manuscript.
Supported by Jiangsu Commission of Health, No. LKZ2023012; Zhenjiang Gastrointestinal Tumor Clinical Key Laboratory, No. SS2023011; New Technology and New Programs of Jiangsu University Hospital, No. xjs2024201; and Science and Technology Planning Project of Zhenjiang City, No. SH2025001.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Ji-Xiang Chen, MD, Chief, Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangsu University, No. 438 Jiefang Road, Jingkou District, Zhenjiang 212000, Jiangsu Province, China. jsdxfsyycjx@163.com
Received: February 2, 2026 Revised: March 6, 2026 Accepted: April 17, 2026 Published online: August 14, 2026 Processing time: 172 Days and 11.4 Hours
Abstract
Laparoscopic endoscopic cooperative surgery (LECS) is a cutting-edge minimally invasive technique, applicable not only in benign gastrointestinal and stromal tumors but also in early gastric cancer (EGC). In EGC management, LECS integrates the benefits of laparoscopy and endoscopy. Endoscopy provides precise localization and accurate submucosal dissection, enabling optimal preservation of healthy gastric tissue. Concurrently, laparoscopy facilitates effective suturing, hemostasis, and management of complications such as perforation, as well as lymph node dissection when required, achieving a balance between functional preservation, oncological efficacy, and procedural safety. This article comprehensively reviews recent developments in LECS for EGC, including its history, indications, clinical outcomes, safety profiles, specific surgical protocols, and role in sentinel lymph node navigation surgery. Additionally, it explores future prospects for LECS in EGC treatment.
Core Tip: Laparoscopic endoscopic cooperative surgery (LECS) represents a paradigm shift in minimally invasive treatment for early gastric cancer (EGC). By synergistically combining endoscopic precision with laparoscopic safety, it achieves an optimal balance between maximal organ preservation and radical oncologic resection, paving the way for function-preserving surgery. This article comprehensively reviews recent developments in LECS for EGC, including its history, indications, clinical outcomes, safety profiles, specific surgical protocols, and role in sentinel lymph node navigation surgery. Additionally, it explores future prospects for LECS in EGC treatment.
