Lin JQ, Liu HZ, Li ZW, Yang K. Intestinal myeloid sarcoma mimicking gastrointestinal stromal tumor without leukemic manifestations: A case report and review of literature. World J Gastroenterol 2026; 32(22): 118810 [DOI: 10.3748/wjg.v32.i22.118810]
Corresponding Author of This Article
Kun Yang, MD, Doctor, Department of General Surgery, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, No. 6 Guangchang Road, Xiaogan 432000, Hubei Province, China. yangkunmedical@163.com
Research Domain of This Article
Gastroenterology & Hepatology
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case-report
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Lin JQ, Liu HZ, Li ZW, Yang K. Intestinal myeloid sarcoma mimicking gastrointestinal stromal tumor without leukemic manifestations: A case report and review of literature. World J Gastroenterol 2026; 32(22): 118810 [DOI: 10.3748/wjg.v32.i22.118810]
World J Gastroenterol. Jun 14, 2026; 32(22): 118810 Published online Jun 14, 2026. doi: 10.3748/wjg.v32.i22.118810
Intestinal myeloid sarcoma mimicking gastrointestinal stromal tumor without leukemic manifestations: A case report and review of literature
Jia-Qing Lin, Han-Zhong Liu, Zi-Wei Li, Kun Yang
Jia-Qing Lin, Kun Yang, Department of General Surgery, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan 432000, Hubei Province, China
Han-Zhong Liu, Zi-Wei Li, Department of Pathology, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan 432000, Hubei Province, China
Author contributions: Lin JQ and Liu HZ managed the case; Lin JQ and Yang K collected and evaluated the data; Lin JQ, Liu HZ, Li ZW and Yang K drafted the manuscript; Yang K revised the manuscript for important intellectual content; all authors have read and approved the final manuscript.
Supported by National Health Commission, Institute level Project of National Key Construction Specialized level Project of General Surgery, No. XGZX202404.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Kun Yang, MD, Doctor, Department of General Surgery, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, No. 6 Guangchang Road, Xiaogan 432000, Hubei Province, China. yangkunmedical@163.com
Received: January 12, 2026 Revised: February 28, 2026 Accepted: March 20, 2026 Published online: June 14, 2026 Processing time: 137 Days and 13.5 Hours
Abstract
BACKGROUND
Myeloid sarcoma is a rare extramedullary tumor of immature myeloid cells, often associated with acute myeloid leukemia. Primary intestinal myeloid sarcoma without hematologic disease is uncommon and can mimic gastrointestinal stromal tumor (GIST).
CASE SUMMARY
A 52-year-old man presented with upper abdominal pain, distension, and nausea. Computed tomography revealed a small intestinal mass with obstruction, suggestive of GIST. Small bowel resection was performed. Intraoperative frozen section suggested lymphoma, but histopathology and immunohistochemistry confirmed myeloid sarcoma [positive for myeloperoxidase, cluster of differentiation (CD) 34, CD117, CD123, CD43]. No evidence of leukemia was identified in peripheral blood or bone marrow examinations. The patient recovered and remained disease-free at 6-month follow-up.
CONCLUSION
Intestinal myeloid sarcoma mimics GIST or lymphoma; definitive diagnosis requires histopathology and immunohistochemistry for appropriate therapy.
Core Tip: This case highlights the diagnostic challenge of intestinal myeloid sarcoma mimicking gastrointestinal stromal tumor, emphasizing the necessity of immunohistochemistry to avoid misdiagnosis and delayed treatment.
