Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2025; 31(6): 101163
Published online Feb 14, 2025. doi: 10.3748/wjg.v31.i6.101163
Short-term efficacy of early percutaneous cholecystostomy for pancreatitis and factors associated with recurrence and mortality
Xin Yan, Feng Xie, Xiao-Dan Zhao, Liang Li, Jia-Xian Meng
Xin Yan, Department of Nuclear Medicine, The People’s Hospital of Liaoning Province, Shenyang 110016, Liaoning Province, China
Feng Xie, Department of Interventional Medicine, Jin Qiu Hospital of Liaoning Province, Shenyang 110016, Liaoning Province, China
Xiao-Dan Zhao, Liang Li, Department of General Surgery, The People’s Hospital of Liaoning Province, Shenyang 110016, Liaoning Province, China
Jia-Xian Meng, Department of Science and Education, The People’s Hospital of Liaoning Province, Shenyang 110016, Liaoning Province, China
Author contributions: Xie F and Zhao XD participated in the conception of the project; Meng JX and Li L revised the manuscript; Yan X was responsible for the writing and editing of the manuscript; and all authors read and approved the final version of the manuscript.
Institutional review board statement: The Institutional Ethics Committee of Liaoning Provincial People’s Hospital approved the study, No. (2023)K037.
Informed consent statement: Written informed consent was obtained from all patients to publish this observation.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Anonymized data not presented herein is available upon reasonable request from the corresponding author on rational request by any qualified researcher.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng Xie, MD, Department of Interventional Medicine, Jin Qiu Hospital of Liaoning Province, No. 317 Xiaonan Road, Shenhe District, Shenyang 110016, Liaoning Province, China. 15040255877@163.com
Received: September 5, 2024
Revised: November 12, 2024
Accepted: December 19, 2024
Published online: February 14, 2025
Processing time: 126 Days and 18.5 Hours
Abstract
BACKGROUND

Percutaneous cholecystostomy (PC) can be used as a bridging therapy for moderately severe acute biliary pancreatitis (MSABP). Currently, there are only a limited number of reports of MSABP using PCs.

AIM

To assess the short-term outcomes of early PC in MSABP and factors associated with recurrence and death in MSABP.

METHODS

Patients who received conservative treatment or PC for acute biliary pancreatitis (ABP) in Liaoning Provincial People’s Hospital from January 2017 to July 2022 were collected. A total of 54 patients with MSABP who received early-stage PC and 29 patients who received conservative treatment. The short-term efficacy of PC was evaluated. Depending on whether there is a recurrence, compare the characteristics of the pre-PC and explore the factors of recurrence. Pre-PC features were compared and predictors were discussed, depending on the outcome.

RESULTS

After 3 days of PC treatment, patients experienced a reduction in inflammatory markers compared to the conservative group. After PC, patients were divided into non-recurrence (n = 37) and recurrence (n = 10) groups, and the results showed that age was an independent correlation affecting ABP recurrence [odds ratio (OR) = 0.937, 95% confidence interval (CI): 0.878-0.999; P = 0.047 < 0.05]. Patient outcomes were divided into non-lethal (n = 47) and lethal (n = 7) groups, and Charlson Comorbidity Index (CCI) was a risk factor for mortality (OR = 2.397, 95%CI: 1.139-5.047; P = 0.021 < 0.05). CCI was highly accurate in predicting death in MSABP (area under the curve = 0.86 > 0.7). When the Youden index maximum was 0.565, the cut-off value was 5.5, the sensitivity was 71.4%, and the specificity was 85.1%.

CONCLUSION

PC is an important method in the early years (< 72 hours) of MSABP. Age is a protective factor against recurrence of ABP. High pre-PC CCI is significantly associated with mortality.

Keywords: Acute biliary pancreatitis; Percutaneous cholecystostomy; The revised Atlanta classification; Charleson Comorbidity Index; Yoden index

Core Tip: We conducted a comparison of percutaneous cholecystostomy before treatment with 3 days of treatment, and between the two modalities after 3 days of treatment, and explored the factors associated with the occurrence of recurrence or death after percutaneous cholecystostomy in patients with moderate to severe acute biliary pancreatitis to deepen our understanding of moderate to severe acute biliary pancreatitis.