Koriem KMM. Duodenal mucosal ablation with irreversible electroporation in non-alcoholic fatty liver disease: Roadmap of the future treatment. World J Gastroenterol 2025; 31(32): 109235 [DOI: 10.3748/wjg.v31.i32.109235]
Corresponding Author of This Article
Khaled Mohamed Mohamed Koriem, PhD, Professor, Department of Medical Physiology, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Buhouth Street, Dokki, P.O. Box, Giza 12622, Egypt. kkoriem@yahoo.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Aug 28, 2025; 31(32): 109235 Published online Aug 28, 2025. doi: 10.3748/wjg.v31.i32.109235
Duodenal mucosal ablation with irreversible electroporation in non-alcoholic fatty liver disease: Roadmap of the future treatment
Khaled Mohamed Mohamed Koriem
Khaled Mohamed Mohamed Koriem, Department of Medical Physiology, Medical Research and Clinical Studies Institute, National Research Centre, Giza 12622, Egypt
Author contributions: Koriem KMM designed the overall concept and outline of the manuscript, contributed to the design of the manuscript, the writing and editing of the manuscript, and review of the literature.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Khaled Mohamed Mohamed Koriem, PhD, Professor, Department of Medical Physiology, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Buhouth Street, Dokki, P.O. Box, Giza 12622, Egypt. kkoriem@yahoo.com
Received: May 6, 2025 Revised: June 4, 2025 Accepted: July 30, 2025 Published online: August 28, 2025 Processing time: 115 Days and 10.7 Hours
Abstract
One of the main causes of liver fibrosis and cancer, non-alcoholic fatty liver disease (NAFLD) is becoming more common every year. The novel work by Yu et al, which evaluates the viability and efficacy of duodenal mucosal ablation (DMA) with irreversible electroporation (IRE) in NAFLD rat models, is examined in this article. When DMA was used with IRE to small rodents, the study found that the duodenum healed successfully two weeks later and had thicker myenterons, narrower and shallower crypts, and slimmer villi than in the sham-control group. When DMA with IRE were used, liver lipid deposition and serum lipid index values decreased; these improvements occurred regardless of food consumption or weight loss. Furthermore, the DMA group's enteroendocrine parameters varied among the various duodenal areas, including claudin and zonula ocludens-1 Levels in the duodenal mucosa. As a result, DMA with IRE in rodents demonstrated no duodenal bleeding or perforation following ablation, providing a promising path for more advanced NAFLD treatment approaches. In order to improve approach outcomes, this paper addresses the implications of extending the study length and animal size, analyzing inflammatory marker studies, and measuring intestinal lipid indexes and endocrine parameters on a weekly basis.
Core Tip: The novel work by Yu et al on the feasibility and efficacy of duodenal mucosal ablation (DMA) with irreversible electroporation (IRE) in non-alcoholic fatty liver disease (NAFLD) rodents is thoroughly examined in this article. The duodenum repaired effectively two weeks after DMA with IRE, according to the study in a sophisticated manner. In NAFLD small rats, the detection of liver lipid deposition, serum lipid parameters, and enteroendocrine parameters such claudin and zonula ocludens-1 levels offer new opportunities for side-effects assessment and advanced therapy approaches.
