Zhou F, Sun YT, Zheng HX, Xiao JD. Mechanism of action of heat-clearing and detoxifying herbs in the treatment of erosive gastritis. World J Gastroenterol 2025; 31(29): 110133 [PMID: 40799369 DOI: 10.3748/wjg.v31.i29.110133]
Corresponding Author of This Article
Hong-Xin Zheng, PhD, Professor, School of Basic Medical Sciences, Liaoning University of Traditional Chinese Medicine, No. 79 Chongshan East Road, Shenyang 110032, Liaoning Province, China. zhenghx2002@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Fang Zhou, Yi-Tong Sun, The First Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China
Hong-Xin Zheng, School of Basic Medical Sciences, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China
Jing-Dong Xiao, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China
Co-corresponding authors: Hong-Xin Zheng and Jing-Dong Xiao.
Author contributions: Zhou F and Sun YT wrote the entire manuscript; Xiao JD and Zheng HX revised and reviewed the final manuscript, and both authors contribute equally to this study as co-corresponding authors.
Supported by National Science and Technology Major Project, No. 2024ZD0521002; The Innovation Team Project of Traditional Chinese Medicine of Liaoning Province, No. LNZYYCXTD-CCCX-003; General Program of the National Natural Science Foundation of China, No. 82074296; and Construction Project of Inheritance Studios of Famous Chinese Medicine Experts in China, No. [2022] No. 75.
Conflict-of-interest statement: Authors declare that they have no competing interests.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Xin Zheng, PhD, Professor, School of Basic Medical Sciences, Liaoning University of Traditional Chinese Medicine, No. 79 Chongshan East Road, Shenyang 110032, Liaoning Province, China. zhenghx2002@126.com
Received: May 30, 2025 Revised: July 1, 2025 Accepted: July 14, 2025 Published online: August 7, 2025 Processing time: 67 Days and 3.4 Hours
Abstract
This article focuses on the clinical efficacy and mechanism of action of heat-clearing and detoxifying traditional Chinese medicines (TCMs) in the treatment of erosive gastritis, providing a reference for the treatment of this disease. In the clinical treatment of erosive gastritis, TCM combinations such as Qing Gastric San, Semixia Diarrheal Heart Soup, and single-flavored heat-clearing and detoxifying drugs such as dandelion and Huanglian have specific efficacies and effectively improve the patient's symptoms, including killing or inhibiting Helicobacter pylori, reducing inflammatory reactions, protecting the gastric mucosa, inhibiting gastric acid secretion, regulating gastrointestinal hormones, and regulating immune function, playing therapeutic roles through multi-level and multi-target mechanisms. Thus, heat-clearing and detoxifying TCMs have broad application prospects in clinical practice for erosive gastritis.
Core Tip: Erosive gastritis, also known as chronic gastritis with erosion, can be divided into two types: "Atrophic gastritis with erosion" and "non-atrophic gastritis with erosion". As a common digestive system disease, the onset of erosive gastritis is related to various factors such as pathogen infection, daily routines, and emotional stress, which seriously affect patient health. The clinical efficacy of heat-clearing and detoxifying traditional Chinese medicine in treating erosive gastritis is definite, and their mechanism of action requires further in-depth research.
