Ardila CM, González-Arroyave D, Ramírez-Arbeláez J. Advancing large language models as patient education tools for inflammatory bowel disease. World J Gastroenterol 2025; 31(20): 105285 [DOI: 10.3748/wjg.v31.i20.105285]
Corresponding Author of This Article
Carlos M Ardila, Department of Basic Sciences, Biomedical Stomatology Research Group, Faculty of Dentistry, Universidad de Antioquia, No. 52-21 Calle 70, Medellín 050010, Antioquia, Colombia. martin.ardila@udea.edu.co
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. May 28, 2025; 31(20): 105285 Published online May 28, 2025. doi: 10.3748/wjg.v31.i20.105285
Advancing large language models as patient education tools for inflammatory bowel disease
Carlos M Ardila, Daniel González-Arroyave, Jaime Ramírez-Arbeláez
Carlos M Ardila, Department of Basic Sciences, Biomedical Stomatology Research Group, Faculty of Dentistry, Universidad de Antioquia, Medellín 050010, Antioquia, Colombia
Carlos M Ardila, Department of Periodontics, Saveetha Dental College, and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Saveetha 600077, India
Daniel González-Arroyave, Department of Surgery, Universidad Pontificia Bolivariana, Medellín 050015, Antioquia, Colombia
Jaime Ramírez-Arbeláez, Department of Transplantation, Hospital San Vicente Fundación, Rionegro 054047, Antioquia, Colombia
Author contributions: Ardila CM performed the conceptualization, data curation, data analysis, manuscript writing, and revision of the manuscript; González-Arroyave D performed the data curation, data analysis, and revision of the manuscript; Ramírez-Arbeláez J performed the data curation, data analysis, and revision of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Carlos M Ardila, Department of Basic Sciences, Biomedical Stomatology Research Group, Faculty of Dentistry, Universidad de Antioquia, No. 52-21 Calle 70, Medellín 050010, Antioquia, Colombia. martin.ardila@udea.edu.co
Received: January 17, 2025 Revised: March 20, 2025 Accepted: April 7, 2025 Published online: May 28, 2025 Processing time: 131 Days and 16.5 Hours
Abstract
This article evaluates the transformative potential of large language models (LLMs) as patient education tools for managing inflammatory bowel disease. The discussion highlights their ability to deliver nuanced and personalized information, addressing limitations in traditional educational materials. Key considerations include the necessity for domain-specific fine-tuning to enhance accuracy, the adoption of robust evaluation metrics beyond readability, and the integration of LLMs with clinical decision support systems to improve real-time patient education. Ethical and accessibility challenges, such as algorithmic bias, data privacy, and digital literacy, are also examined. Recommendations emphasize the importance of interdisciplinary collaboration to optimize LLM integration, ensuring equitable access and improved patient outcomes. By advancing LLM technology, healthcare can empower patients with accurate and personalized information, enhancing engagement and disease management.
Core Tip: Large language models offer a groundbreaking approach to patient education for inflammatory bowel disease by providing accurate, personalized, and nuanced information. This article emphasizes the need for domain-specific fine-tuning of large language models, robust evaluation metrics, and their integration into clinical workflows. Ethical concerns, such as algorithmic bias and patient data privacy, and accessibility barriers, including digital literacy gaps, are critical to address. Interdisciplinary collaboration is essential for optimizing these tools to enhance patient engagement and improve health outcomes.