Published online Feb 28, 2024. doi: 10.3748/wjg.v30.i8.969
Peer-review started: October 25, 2023
First decision: December 21, 2023
Revised: January 2, 2024
Accepted: February 1, 2024
Article in press: February 1, 2024
Published online: February 28, 2024
Processing time: 124 Days and 2.4 Hours
Three-dimensional organoid culture systems have been established as a robust tool for elucidating mechanisms and performing drug efficacy testing. The use of gastric organoid models holds significant promise for advancing personalized medicine research. However, a comprehensive bibliometric review of this bur-geoning field has not yet been published.
To analyze and understand the development, impact, and direction of gastric organoid research using bibliometric methods using data from the Web of Science Core Collection (WoSCC) database.
This analysis encompassed literature pertaining to gastric organoids published between 2010 and 2023, as indexed in the WoSCC. CiteSpace and VOSviewer were used to depict network maps illustrating collaborations among authors, institutions and keywords related to gastric organoid. Citation, co-citation, and burst analysis methodologies were applied to assess the impact and progress of research.
A total of 656 relevant studies were evaluated. The majority of research was published in gastroenterology-focused journals. Globally, Yana Zavros, Hans Clevers, James M Wells, Sina Bartfeld, and Chen Zheng were the 5 most productive authors, while Hans Clevers, Huch Meritxell, Johan H van Es, Marc Van de Wetering, and Sato Toshiro were the foremost influential scientists in this area. Institutions from the University Medical Center Utrecht, Netherlands Institute for Developmental Biology (Utrecht), and University of Cincinnati (Cincinnati, OH, United States) made the most significant contributions. Currently, gastric organoids are used mainly in studies investigating gastric cancer (GC), Helicobacter pylori-infective gastritis, with a focus on the mechanisms of GC, and drug screening tests.
Key focus areas of research using gastric organoids include unraveling disease mechanisms and enhancing drug screening techniques. Major contributions from renowned academic institutions highlight this field’s dynamic growth.
Core Tip: This study highlights the pivotal role of organoid technology in gastric disease research, emphasizing its growth in publications and citations. Key contributions from leading researchers and institutions, particularly in understanding gastric cancer and Helicobacter pylori-infective gastritis, mark advances in the field. Focused on deciphering cancer mechanisms and improving drug screening, this area of exploration provides crucial insights for future gastroenterology research.