Bai-Wei Zhao, Ruo-Peng Zhang, Yong-Ming Chen, Bo-Wen Huang, Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, Guangdong Province, China
Ying-Jia Chen, Health Science Center, Peking University, Beijing 100191, China
Co-first authors: Bai-Wei Zhao and Ying-Jia Chen.
Author contributions: Zhao BW and Chen YJ share the first author; Huang BW and Chen YJ designed research; Zhao BW and Zhang RP performed research; Chen YJ and Chen YM wrote the letter; Huang BW and Zhao BW revised the letter.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Bo-Wen Huang, MD, Professor, Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, No. 651 Dongfeng East Road, Yuexiu District, Guangzhou 510060, Guangdong Province, China. huangbw1@sysucc.org.cn
Received: October 31, 2023 Peer-review started: October 31, 2023 First decision: December 6, 2023 Revised: December 17, 2023 Accepted: January 15, 2024 Article in press: January 15, 2024 Published online: February 14, 2024 Processing time: 97 Days and 1.9 Hours
Abstract
The present letter to the editor is related to the study titled ‘Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells’. Angiotensin-converting enzyme 2 can alleviate liver fibrosis by regulating autophagy of hepatic stellate cells and affecting the renin-angiotensin system.
Core Tip: This letter to the editor adds to the ongoing conversation regarding the involvement of angiotensin-converting enzyme 2 (ACE2) in liver fibrosis from the perspective of its effect on the renin-angiotensin system (RAS). The major highlight of this letter is the discussion of the role of ACE2 in regulating liver fibrosis through RAS beyond the pathway studied in the article titled ‘Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells’.
