Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2024; 30(44): 4741-4744
Published online Nov 28, 2024. doi: 10.3748/wjg.v30.i44.4741
Role of different examination methods in colorectal cancer screening: Insights and future directions
Qiu-Ning Liu, Yang Ye, Xiao-Qiang Jia
Qiu-Ning Liu, Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China
Yang Ye, Department of Traditional Chinese Medicine, Peking University Third Hospital, Beijing 100191, China
Xiao-Qiang Jia, Department of Anorectal, Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China
Co-corresponding authors: Yang Ye and Xiao-Qiang Jia.
Author contributions: Liu QN wrote the first draft of the manuscript; Ye Y contributed to review and editing; Ye Y and Jia XQ conceived, reviewed, and revised this paper; Ye Y and Jia XQ contributed equally and share the corresponding authorship.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yang Ye, PhD, Research Assistant, Department of Traditional Chinese Medicine, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China. yeyang89@bjmu.edu.cn
Received: July 18, 2024
Revised: September 26, 2024
Accepted: October 23, 2024
Published online: November 28, 2024
Processing time: 116 Days and 19.2 Hours
Abstract

Colorectal cancer is a malignant tumor with the third and second highest incidence and mortality rates worldwide, and its mortality rate is increasing annually. Colorectal cancer evolves gradually over a long period of time. The evolving process from colorectal adenoma to colorectal cancer takes approximately 10-15 years, providing a sufficiently long "window period" for early screening and diagnosis of colorectal cancer. The recurrence and mortality rates can be controlled at a low level with an early intervention. Metaxas et al sum-marized existing screening methods and their applicable scope in a recent publication. Moreover, they provide suggestions on how to improve adherence. This editorial provides a commentary on their article and discuss the roles of different screening methods in the early screening of colorectal cancer.

Keywords: Colorectal cancer; Early screening of tumors; Non-invasive liquid tissue biopsy; Research progress

Core Tip: We comment on an article by Metaxas et al. This study emphasizes the importance of early screening in colorectal cancer and provides a summary of the common screening methods. Moreover, this study notes that invasive examinations are not easily accepted by patients and provides a detailed introduction to the applicability, sensitivity, and accuracy of noninvasive examinations. Finally, we propose methods that may help improve adherence rates. Here, we offer insights into their article and discuss relevant topics within this field.