Lipid metabolism-related long noncoding RNAs: A potential prognostic biomarker for hepatocellular carcinoma

doi:10.3748/wjg.v30.i33.3799

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Sep 7, 2024 (publication date) through Feb 23, 2026

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2024; 30(33): 3799-3802
Published online Sep 7, 2024. doi: 10.3748/wjg.v30.i33.3799

Lipid metabolism-related long noncoding RNAs: A potential prognostic biomarker for hepatocellular carcinoma

Rui-Nan Zhang, Jian-Gao Fan

Rui-Nan Zhang, Jian-Gao Fan, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China

Author contributions: Fan JG designed the overall concept and outlined the manuscript; Zhang RN reviewed the literature, wrote and edited the manuscript; Both authors have read and approved the final version to be published.

Supported by National Natural Science Foundation of China, No. 82170593, No. 81700503; and the National Key Research and Development Program of China, No. 2021YFC2700802.

Conflict-of-interest statement: All the authors have nothing to disclose.

Corresponding author: Jian-Gao Fan, MD, PhD, Director, Professor, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Shanghai 200092, China. fanjiangao@xinhuamed.com.cn

Received: March 26, 2024
Revised: August 13, 2024
Accepted: August 16, 2024
Published online: September 7, 2024
Processing time: 159 Days and 11.4 Hours

Abstract

The incidence rates of hepatocellular carcinoma (HCC) have increased in recent decades. Despite advancements in therapy and early diagnosis improving short-term prognosis, long-term outcomes remain poor. Long noncoding RNAs (lncRNAs) and lipid metabolism play crucial roles in the development and progression of HCC. Enhanced lipid synthesis promotes HCC progression, and lncRNAs can reprogram the expression of lipogenic enzymes. Consequently, lipid metabolism-related (LMR)-lncRNAs regulate lipid anabolism, accelerating the onset and progression of HCC. This suggests that LMR-lncRNAs could serve as novel prognostic biomarkers and therapeutic targets.

Keywords: Long noncoding RNAs; Lipid metabolism; Hepatocellular carcinoma; Prognosis; Biomarker

Core Tip: Lipid metabolism and long noncoding RNAs (lncRNAs) are pivotal in hepatocellular carcinoma (HCC) development. While the prognosis of HCC remains poor and prognostic biomarkers are lacking, lipid metabolism-related lncRNAs may be promising candidates for prognostic biomarkers in HCC.