Tata-box-binding protein-associated factor 15 as a new potential marker in gastrointestinal tumors

Abstract

In this editorial, the roles of tata-box-binding protein-associated factor 15 (TAF15) in oncogenesis, tumor behavior, and as a therapeutic target in cancers in the context of gastrointestinal (GI) tumors are discussed concerning the publication by Guo et al. TAF15 is a member of the FET protein family with a comprehensive range of cellular processes. Besides, evidence has shown that TAF15 is involved in many diseases, including cancers. TAF15 contributes to carcinogenesis and tumor behavior in many tumors. Besides, its relationship with the mitogen-activated protein kinases (MAPK) signaling pathway makes TAF15 a new target for therapy. Although, the fact that there is few studies investigating the expression of TAF15 constitutes a potential limitation in GI system, the association of TAF15 expression with aggressive tumor behavior and, similar to other organ tumors, the influence of TAF15 on the MAPK signaling pathway emphasize that this protein could serve as a new molecular biomarker to predict tumor behavior and target therapeutic intervention in GI cancers. In conclusion, more studies should be performed to better understand the prognostic and therapeutic role of TAF15 in GI tumors, especially in tumors resistant to therapy.

Keywords: Gastrointestinal cancer; Tata-box-binding protein-associated factor 15; Cell proliferation; Cell migration; Prognosis

Core Tip: Recently, the role of tata-binding protein associated factor 15 (TAF15) in many diseases, including cancer, has been suggested. Current results support the hypothesis that TAF15 expression is related to aggressive behavior by contributing to many pathways that are involved in tumor progression. Although its role in prognosis has not been entirely determined in gastrointestinal cancers, the fact that increased TAF15 expression is associated with adverse clinicopathological parameters warrants further study with the aim of better understanding its role in predicting prognosis. Moreover, based on its association with the mitogen-activated protein kinases signal pathway, its significance as a therapeutic target, particularly in tumors resistant to treatment awaits investigation.