Chronic active and atrophic gastritis as significant contributing factor to the development of gastric cystica profunda

doi:10.3748/wjg.v30.i17.2308

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May 7, 2024 (publication date) through Feb 27, 2026

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 7, 2024; 30(17): 2308-2310
Published online May 7, 2024. doi: 10.3748/wjg.v30.i17.2308

Chronic active and atrophic gastritis as significant contributing factor to the development of gastric cystica profunda

Veronika Papp, Pál Miheller

Veronika Papp, Pál Miheller, Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, Budapest 1082, Hungary

Author contributions: Papp V and Miheller P contributed equally to this work.

Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.

Corresponding author: Veronika Papp, MD, PhD, Adjunct Professor, Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, 78 Üllői Street, Budapest 1082, Hungary. papp.veronika@semmelweis.hu

Received: February 18, 2024
Revised: March 20, 2024
Accepted: April 15, 2024
Published online: May 7, 2024
Processing time: 76 Days and 11.3 Hours

Abstract

Gastric cystica profunda (GCP) is an uncommon but underestimated gastric lesion. Its precancerous potential determines its significance. In addition to previous mucosa injury due to operations, biopsy or polypectomy, chronic active and atrophic gastritis may also lead to the development of GCPs. By carefully examining the stomach and taking biopsy samples from the susceptible regions, the stage of atrophy can be determined. Chronic atrophic gastritis is a risk factor for cancer evolvement and it can also contribute to GCPs formation. GCPs frequently occur close to early gastric cancers (EGCs) or EGC can arise from the cystic glands. Endoscopic resection is an effective and minimally invasive treatment in GCP.

Keywords: Gastric cystica profunda; Chronic active gastritis; Atrophic gastritis; Operative Link for Gastritis Assessment staging; Early gastric cancer; Endoscopic resection

Core Tip: Gastric cystica profunda (GCP) is a premalignant lesion developing on basis of ischemia. Chronic active or atrophic gastritis are considered to be a significant etiological factors in the development of GCPs and carry a risk for cancer formation. GCPs, with or without early gastric cancer, can be removed effectively by endoscopic resection.