Probiotics: Shaping the gut immunological responses

Abstract

Probiotics are live microorganisms exerting beneficial effects on the host’s health when administered in adequate amounts. Among the most popular and adequately studied probiotics are bacteria from the families Lactobacillaceae, Bifidobacteriaceae and yeasts. Most of them have been shown, both in vitro and in vivo studies of intestinal inflammation models, to provide favorable results by means of improving the gut microbiota composition, promoting the wound healing process and shaping the immunological responses. Chronic intestinal conditions, such as inflammatory bowel diseases (IBD), are characterized by an imbalance in microbiota composition, with decreased diversity, and by relapsing and persisting inflammation, which may lead to mucosal damage. Although the results of the clinical studies investigating the effect of probiotics on patients with IBD are still controversial, it is without doubt that these microorganisms and their metabolites, now named postbiotics, have a positive influence on both the host’s microbiota and the immune system, and ultimately alter the topical tissue microenvironment. This influence is achieved through three axes: (1) By displacement of potential pathogens via competitive exclusion; (2) by offering protection to the host through the secretion of various defensive mediators; and (3) by supplying the host with essential nutrients. We will analyze and discuss almost all the in vitro and in vivo studies of the past 2 years dealing with the possible favorable effects of certain probiotic genus on gut immunological responses, highlighting which species are the most beneficial against intestinal inflammation.

Keywords: Probiotics; Lactobacillaceae; Bifidobacteriaceae; Saccharomyces; Intestinal inflammation; Immune responses

Core Tip: Probiotics, such as Lactiplantibacillus plantarum and Saccharomyces cerevisiae, exert remarkable anti-inflammatory properties on the gut's immune responses. These beneficial microorganisms not only restore immunity markers but also enrich the gut's microbiota, crucial for a healthy microbial balance. Incorporating probiotics or foods rich in these beneficial microorganisms, particularly in conditions such as inflammatory bowel disease, holds promise for restoring gut health, boosting the immune system, and alleviating inflammation.