Published online Mar 21, 2024. doi: 10.3748/wjg.v30.i11.1488
Peer-review started: January 3, 2024
First decision: January 19, 2024
Revised: January 30, 2024
Accepted: February 28, 2024
Article in press: February 28, 2024
Published online: March 21, 2024
Processing time: 78 Days and 7.1 Hours
The last decade has been notable for increasing high-quality research and dramatic improvement in outcomes with dynamic liver preservation. Robust evidence from numerous randomized controlled trials has been pooled by meta-analyses, providing the highest available evidence on the protective effect of machine perfusion (MP) over static cold storage in liver transplantation (LT). Based on a protective effect with less complications and improved graft survival, the field has seen a paradigm shift in organ preservation. This editorial focuses on the role of MP in LT and how it could become the new “gold standard”. Strong collaborative efforts are needed to explore its effects on long-term outcomes.
Core Tip: Machine perfusion (MP) has garnered the interest of the transplant community given its proven beneficial effects on the clinical outcomes after liver transplantation (LT). Herein, we discuss the historical background of MP in LT and the available clinical evidence. Furthermore, we highlighted the obstacles and the need for future research, in particular with respect to viability assessment and prolonged preservation times.