Parente A, Sun K, Dutkowski P, Shapiro AJ, Schlegel A. Routine utilization of machine perfusion in liver transplantation: Ready for prime time? World J Gastroenterol 2024; 30(11): 1488-1493 [PMID: 38617447 DOI: 10.3748/wjg.v30.i11.1488]
Corresponding Author of This Article
Alessandro Parente, FEBS, MD, PhD, Surgeon, Department of Surgery, Division of Transplantation, University of Alberta Hospital, No. 8440 112 St NW, Edmonton T6G 2B7, Canada. aleparen@gmail.com
Research Domain of This Article
Transplantation
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Mar 21, 2024; 30(11): 1488-1493 Published online Mar 21, 2024. doi: 10.3748/wjg.v30.i11.1488
Routine utilization of machine perfusion in liver transplantation: Ready for prime time?
Alessandro Parente, Keyue Sun, Philipp Dutkowski, AM James Shapiro, Andrea Schlegel
Alessandro Parente, AM James Shapiro, Department of Surgery, Division of Transplantation, University of Alberta Hospital, Edmonton T6G 2B7, Canada
Keyue Sun, Immunity and Inflammation, Lerner Research Institute, Cleveland, OH 44195, United States
Philipp Dutkowski, Swiss Hepato-Pancreato-Biliary Center, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich 8091, Switzerland
Andrea Schlegel, Immunity and Inflammation, Digestive Disease and Surgery Institute, Cleveland, OH 44195, United States
Author contributions: Parente A and Schlegel A designed research; Parente A and Schlegel A wrote the manuscript; Sun K, Shapiro AMJ and Dutkowski P revised the manuscript. All authors approved the final version of the manuscript.
Conflict-of-interest statement: All authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Alessandro Parente, FEBS, MD, PhD, Surgeon, Department of Surgery, Division of Transplantation, University of Alberta Hospital, No. 8440 112 St NW, Edmonton T6G 2B7, Canada. aleparen@gmail.com
Received: January 3, 2024 Peer-review started: January 3, 2024 First decision: January 19, 2024 Revised: January 30, 2024 Accepted: February 28, 2024 Article in press: February 28, 2024 Published online: March 21, 2024 Processing time: 78 Days and 7.1 Hours
Abstract
The last decade has been notable for increasing high-quality research and dramatic improvement in outcomes with dynamic liver preservation. Robust evidence from numerous randomized controlled trials has been pooled by meta-analyses, providing the highest available evidence on the protective effect of machine perfusion (MP) over static cold storage in liver transplantation (LT). Based on a protective effect with less complications and improved graft survival, the field has seen a paradigm shift in organ preservation. This editorial focuses on the role of MP in LT and how it could become the new “gold standard”. Strong collaborative efforts are needed to explore its effects on long-term outcomes.
Core Tip: Machine perfusion (MP) has garnered the interest of the transplant community given its proven beneficial effects on the clinical outcomes after liver transplantation (LT). Herein, we discuss the historical background of MP in LT and the available clinical evidence. Furthermore, we highlighted the obstacles and the need for future research, in particular with respect to viability assessment and prolonged preservation times.
