Effect of octreotide on cell-cycle kinetics and serum carcinoembryonic antigen level in hepatic metastases of colonic adenocarcinoma

doi:10.3748/wjg.v3.i2.69

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Jun 15, 1997 (publication date) through Feb 24, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 15, 1997; 3(2): 69-71
Published online Jun 15, 1997. doi: 10.3748/wjg.v3.i2.69

Effect of octreotide on cell-cycle kinetics and serum carcinoembryonic antigen level in hepatic metastases of colonic adenocarcinoma

Rui Liu, Yuan-He Wang, Yan Tang, Gui-Song Cao

Rui Liu, Yuan-He Wang, Yan Tang, Gui-Song Cao, Department of Surgery, Changhai Hospital, Shanghai 200433, China

Yuan-He Wang, General Surgery, Changzheng Hospital, Shanghai 200003, China

Rui Liu, male, born on June 11, 1962 in You County, Hunan Province, graduated from the Department of Medicine in the Second Military Medical University, Attending doctor, engaged in clinical and experimental study on gastroenterologic, pancreatic and splenic diseases, having 16 papers published.

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Rui Liu, Department of Surgery, Changhai Hospital, 170 Changhailu, Shanghai 200433, China

Received: September 30, 1996
Revised: February 15, 1997
Accepted: April 1, 1997
Published online: June 15, 1997

Abstract

AIM: To study the inhibitory effect of somatostatin analogue (octreotide) on tumor growth.

METHODS: The influence of cell-cycle kinetics on hepatic metastases of BALB/c mice colonic adenocarcinoma (CT26) with octreotide treatment in vivo was investigated by flow cytometry. The serum carcinoembryonic antigen (CEA) levels were also determined.

RESULTS: The results showed that the proliferative index (PI) and the S-phase fraction in hepatic tumors of mice treated with octreotide decreased markedly and that the G₀/G₁ serum CEA phase fraction increased significantly in comparison with the control (P < 0.01). After administration of octreotide, the serum CEA levels were also lower than those in the control group. The incidence of liver metastases in the treated group was lower than that in the control. The body weight loss in the mice was slower and survival was longer in the treated group than in the control group. Furthermore, the changes in PI and the fraction distribution of S-phase or G₀/G_1-phase in cell cycle were closely related to the serum CEA levels.

CONCLUSION: Octreotide may be useful for inhibiting the hepatic metastases of colonic carcinoma.

Keywords: Colonic neoplasms; Liver neoplasms/secondary; adenocarcinoma; Cytometry; Octreotide; Carcinoembryonic antigen/analysis