Relationship between loss of heterozygosity of deleted in colorectal carcinoma gene microsatellites and prognosis of colorectal adenocarcinoma

doi:10.3748/wjg.v3.i2.121

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Jun 15, 1997 (publication date) through Mar 5, 2026

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 15, 1997; 3(2): 121-122
Published online Jun 15, 1997. doi: 10.3748/wjg.v3.i2.121

Relationship between loss of heterozygosity of deleted in colorectal carcinoma gene microsatellites and prognosis of colorectal adenocarcinoma

Po Zhao, Ying-Chuan Yu, De-Wen Wang, Zhi-Ping Wang, Xin-Zhao Xu, Ping-Yong Yi, Ya-Bing Gao, Guang-Hua Yang

Po Zhao, Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China

Ying-Chuan Yu, Ping-Yong Yi, Guang-Hua Yang, Department of Pathology, West China University of Medical Sciences, Chengdu 610041, Sichuan Province, China

De-Wen Wang, Zhi-Ping Wang, Ya-Bing Gao, Department of Pathology, Academy of Military Medical Sciences, Beijing 100850, China

Xin-Zhao Xu, Department of Pathology, General Hospital of Chinese PLA, Jinan Command Area

Po Zhao, MD and PhD, Associate Professor of Pathology, Head of Molecular Pathology Lab, has published 40 papers.

Author contributions: All authors contributed equally to the work.

Supported by The Scientific Foundation for Chinese Postdoctorates, No. 1994-3.

Correspondence to: Dr. Po Zhao, MD and PhD, Associate Professor, Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China

Telephone: +86-10-66887329-6253

Received: October 25, 1996
Revised: January 31, 1997
Accepted: March 1, 1997
Published online: June 15, 1997

Abstract

AIM: To investigate the relationship between the loss of heterozygosity (LOH) of microsatellites on the deleted in colorectal carcinoma (DCC) gene and prognosis of colorectal adenocarcinoma.

METHODS: A retrospective study of 58 colorectal adenocarcinoma cases with follow-up data and paired control normal mucosal tissues from 1983 to 1985 from files from the West China University of Medical Sciences Department of Pathology was carried out by PCR microsatellite analysis. Sixteen, 35, and seven cases had well-, moderately, and poorly differentiated tumors, respectively; 11, 30, and 17 cases were staged as Dukes’ A, B, and C, respectively.

RESULTS: LOH of DCC microsatellites was detected in 18 cases (31.0%). The 5-year survival rate between LOH-positive and LOH-negative patients was 44.4% and 77.5%, respectively (P < 0.05). The results suggest that LOH of DCC microsatellites correlate with prognosis but not with differentiation (P > 0.05) and Dukes’ stage (P > 0.05) in colorectal adenocarcinoma.

CONCLUSION: LOH of DCC microsatellites may be a marker of malignancy. Combined with the traditional prognostic indicators, LOH can predict prognosis of colorectal adenocarcinoma.

Keywords: Colorectal neoplasms; Polymerase chain reaction (PCR); Oncogenes; Adenocarcinoma; Heterozygote; Prognosis