Published online Aug 21, 2023. doi: 10.3748/wjg.v29.i31.4736
Peer-review started: June 26, 2023
First decision: July 5, 2023
Revised: July 17, 2023
Accepted: July 28, 2023
Article in press: July 28, 2023
Published online: August 21, 2023
Processing time: 53 Days and 8.5 Hours
Diabetes is a highly prevalent disease that was initially simplified into three major types: Type 1, type 2 and gestational diabetes. With the global rise in incidence of acute pancreatitis (AP), a lesser-known type of diabetes referred to as diabetes of the exocrine pancreas (DEP) is becoming more recognized. However, there is a poor understanding of the inherent relationship between diabetes and AP. There is established data about certain diseases affecting the exocrine function of the pancreas which can lead to diabetes. More specifically, there are well established guidelines for diagnosis and management of DEP caused be chronic pancreatitis. Conversely, the sequelae of AP leading to diabetes has limited recognition and data. The purpose of this review is to provide a comprehensive summary of the prevalence, epidemiology, pathophysiology and future research aims of AP-related diabetes. In addition, we propose a screening and diagnostic algorithm to aid clinicians in providing better care for their patients.
Core Tip: Acute pancreatitis (AP)-related diabetes has limited recognition and data. The disease occurs more often than previously recognized and patients are often misdiagnosed with type 2 diabetes. The purpose of this review is to provide a comprehensive summary of the prevalence, epidemiology, pathophysiology and future research aims of AP-related diabetes. In addition, we propose a screening and diagnostic algorithm to aid clinicians in providing better care for their patients.