Can visceral fat parameters based on computed tomography be used to predict occult peritoneal metastasis in gastric cancer?

Abstract

BACKGROUND

The preoperative prediction of peritoneal metastasis (PM) in gastric cancer would prevent unnecessary surgery and promptly indicate an appropriate treatment plan.

AIM

To explore the predictive value of visceral fat (VF) parameters obtained from preoperative computed tomography (CT) images for occult PM and to develop an individualized model for predicting occult PM in patients with gastric carcinoma (GC).

METHODS

A total of 128 confirmed GC cases (84 male and 44 female patients) that underwent CT scans were analyzed and categorized into PM-positive (n = 43) and PM-negative (n = 85) groups. The clinical characteristics and VF parameters of two regions of interest (ROIs) were collected. Univariate and stratified analyses based on VF volume were performed to screen for predictive characteristics for occult PM. Prediction models with and without VF parameters were established by multivariable logistic regression analysis.

RESULTS

The mean attenuations of VF_{ROI 1} and VF_{ROI 2} varied significantly between the PM-positive and PM-negative groups (P = 0.044 and 0.001, respectively). The areas under the receiver operating characteristic curves (AUCs) of VF_{ROI 1} and VF_{ROI 2} were 0.599 and 0.657, respectively. The mean attenuation of VF_{ROI 2} was included in the final prediction combined model, but not an independent risk factor of PM (P = 0.068). No significant difference was observed between the models with and without mean attenuation of VF (AUC: 0.749 vs 0.730, P = 0.339).

CONCLUSION

The mean attenuation of VF is a potential auxiliary parameter for predicting occult PM in patients with GC.

Keywords: Gastric carcinoma; Peritoneal metastasis; Visceral fat; Tomography; X-ray computed; Prediction; Individualized model

Core Tip: The preoperative prediction of peritoneal metastasis (PM) in gastric cancer would prevent unnecessary surgery and promptly indicate an appropriate treatment plan. We therefore aimed to explore the predictive value of visceral fat (VF) parameters obtained from preoperative computed tomography images for occult PM and to develop an individualized model for predicting occult PM in patients with gastric carcinoma (GC). Consequently, mean attenuation of VF is a potential auxiliary parameter to predict occult PM in patients with GC.