Emerging role of non-invasive and liquid biopsy biomarkers in pancreatic cancer

doi:10.3748/wjg.v29.i15.2241

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 29, Issue 15

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (11224)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Tables (1-4) series.

Item

Count

PDF

417

WORD

HTML

7789

Tables (1-4)

658

Sum=8923

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

326

Download

816

Sum=1142

Publishing Process of This Article

Item

Count

Browse

333

Download

828

Sum=1161

Apr 21, 2023 (publication date) through Mar 8, 2026

Times Cited of This Article

Times Cited (15)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Review

World J Gastroenterol. Apr 21, 2023; 29(15): 2241-2260
Published online Apr 21, 2023. doi: 10.3748/wjg.v29.i15.2241

Emerging role of non-invasive and liquid biopsy biomarkers in pancreatic cancer

Akash Bararia, Prosenjeet Chakraborty, Paromita Roy, Bitan Kumar Chattopadhay, Amlan Das, Aniruddha Chatterjee, Nilabja Sikdar

Akash Bararia, Nilabja Sikdar, Human Genetics Unit, Indian Statistical Institute, Kolkata 700108, India

Prosenjeet Chakraborty, Department of Molecular Biosciences, SVYASA School of Yoga and Naturopathy, Bangalore 560105, India

Paromita Roy, Department of Pathology, Tata Medical Center, Kolkata 700160, India

Bitan Kumar Chattopadhay, Department of General Surgery, IPGMER & SSKM Hospital, Kolkata 700020, India

Amlan Das, Department of Biochemistry, Royal Global University, Assam 781035, India

Aniruddha Chatterjee, Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9061, New Zealand

Aniruddha Chatterjee, School of Health Sciences and Technology, University of Petroleum and Energy Studies, Dehradun 248007, India

Author contributions: Bararia A and Chakraborty P wrote the first draft of the paper and constructed the flow chart and tables; Chatterjee A, Roy P, Chattopadhay B K, Das A and Sikdar N provided valuable input, suggestions, comments and guidance while writing the review manuscript and contributed to proofreading and editing; Sikdar N constructed, wrote, conceptualized, and edited the review manuscript.

Supported by the Department of Biotechnology, Government of India Grant Sanction, Ramalingaswami Re-entry Fellowship, No. RLS/BT/Re-entry/05/2012.

Conflict-of-interest statement: The authors declare no conflicts of interest.

Corresponding author: Nilabja Sikdar, PhD, Research Scientist, Doctor, Human Genetics Unit, Indian Statistical Institute, 203, B.T. Road, Kolkata 700108, India. snilabja@isical.ac.in

Received: November 28, 2022
Peer-review started: November 28, 2022
First decision: January 11, 2023
Revised: February 2, 2023
Accepted: March 15, 2023
Article in press: March 15, 2023
Published online: April 21, 2023
Processing time: 136 Days and 23.7 Hours

Abstract

A global increase in the incidence of pancreatic cancer (PanCa) presents a major concern and health burden. The traditional tissue-based diagnostic techniques provided a major way forward for molecular diagnostics; however, they face limitations based on diagnosis-associated difficulties and concerns surrounding tissue availability in the clinical setting. Late disease development with asymptomatic behavior is a drawback in the case of existing diagnostic procedures. The capability of cell free markers in discriminating PanCa from autoimmune pancreatitis and chronic pancreatitis along with other precancerous lesions can be a boon to clinicians. Early-stage diagnosis of PanCa can be achieved only if these biomarkers specifically discriminate the non-carcinogenic disease stage from malignancy with respect to tumor stages. In this review, we comprehensively described the non-invasive disease detection approaches and why these approaches are gaining popularity for their early-stage diagnostic capability and associated clinical feasibility.

Keywords: Non-invasive biomarkers; Cell free biomarkers; Proteomic biomarkers; Liquid biopsy-based diagnostics; Pancreatic cancer biomarkers

Core Tip: Considering the limited commercial availability of cell free nucleic acids and secreted proteome-based non-invasive biomarkers it is crucial to summarize them for the proper diagnosis of pancreatic cancer and distinguish it from other benign pancreatic diseases. We also highlighted the clinical use of these non-invasive biomarkers in diagnostics. This review will successfully guide readers to address the current issues and aid in the cutting-edge development of biomarkers with higher sensitivity and specificity.