Published online Mar 28, 2023. doi: 10.3748/wjg.v29.i12.1852
Peer-review started: December 5, 2022
First decision: February 8, 2023
Revised: February 11, 2023
Accepted: March 14, 2023
Article in press: March 14, 2023
Published online: March 28, 2023
Processing time: 113 Days and 1.8 Hours
The presentation, subtype, and macroscopic images of lymphoma vary depending on the site of the tumor within the gastrointestinal tract. We searched PubMed for publications between January 1, 2012 and October 10, 2022, and retrieved 130 articles relating to duodenal lymphoma. A further 22 articles were added based on the manual screening of relevant articles, yielding 152 articles for full-text review. The most predominant primary duodenal lymphoma was follicular lymphoma. In this review, we provide an update of the diagnosis and man-agement of representative lymphoma subtypes occurring in the duodenum: Follicular lymphoma, diffuse large B-cell lymphoma, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue, mantle cell lymphoma, and T-cell lymphomas.
Core Tip: Among cases of primary duodenal lymphoma, follicular lymphoma was the most predominant, followed by diffuse large B-cell lymphoma, extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT lymphoma), mantle cell lymphoma, and T-cell lymphomas. A watch and wait policy is acceptable for follicular lymphoma. Observation without treatment is also an option for MALT lymphoma. However, it should be noted that duodenal MALT lymphoma has a higher rate of transformation to diffuse large B-cell lymphoma than gastric MALT lymphoma. Diffuse large B-cell lymphoma, mantle cell lymphoma, and T-cell lymphomas generally require systemic treatment.