Promising role of D-amino acids in irritable bowel syndrome

Abstract

Irritable bowel syndrome (IBS) is an important health care concern. Alterations in the microbiota of the gut-brain axis may be linked to the pathophysiology of IBS. Some dietary intake could contribute to produce various metabolites including D-amino acids by the fermentation by the gut microbiota. D-amino acids are the enantiomeric counterparts of L-amino acids, in general, which could play key roles in cellular physiological processes against various oxidative stresses. Therefore, the presence of D-amino acids has been shown to be linked to the protection of several organs in the body. In particular, the gut microbiota could play significant roles in the stability of emotion via the action of D-amino acids. Here, we would like to shed light on the roles of D-amino acids, which could be used for the treatment of IBS.

Keywords: Irritable bowel syndrome; D-amino acid; Gut microbiota; Colitis; Probiotics; Fecal microbiota transplantation

Core Tip: The potential efficacy of D-amino acids for the treatment of irritable bowel syndrome is shown here.