Basic Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2022; 28(13): 1329-1337
Published online Apr 7, 2022. doi: 10.3748/wjg.v28.i13.1329
Comparison of the performance of MS enteroscope series and Japanese double- and single-balloon enteroscopes
Jin-Hua Liu, Dan-Yang Liu, Yong-Feng Yuan, Xue-Jun Sun, Shu-Mei Shan
Jin-Hua Liu, Xue-Jun Sun, Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Jin-Hua Liu, Department of General Surgery, Affiliated Dalian Municipal Friendship Hospital of Dalian Medical University, Dalian 116001, Liaoning Province, China
Dan-Yang Liu, Department of Endocrinology, Affiliated Dalian Municipal Friendship Hospital of Dalian Medical University, Dalian 116001, Liaoning Province, China
Yong-Feng Yuan, College of Computer Science and Technology, Harbin Institute of Technology, Harbin 150001, Heilongjiang Province, China
Shu-Mei Shan, General Manager Office, Dalian Ming Sheng Technology Development Co., Ltd., Dalian 116001, Liaoning Province, China
Author contributions: Liu JH, Liu DY and Sun XJ designed the research; Liu JH, Liu DY, Yuan YF, Sun XJ and Shan SM performed the research; Liu JH, Liu DY and Sun XJ contributed new reagents/analytic tools; Liu JH analyzed the data; Liu JH and Sun XJ wrote the paper.
Supported by the 2020 Liaoning Provincial Natural Science Foundation General Project, No. 2020-MS-332.
Institutional review board statement: The study was reviewed and approved by the Academic Committee of Dalian Friendship Hospital Institutional Review Board [(Approval No. YY-XS-2019-001-1]).
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Ethics Committee of Dalian Friendship Hospital (IACUC protocol number: [Protocol No. YY-LL-2020-015]).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: Xue-Jun Sun has received fees for serving as a speaker for The First Affiliated Hospital of Xi'an Jiaotong University; Jin-Hua Liu has received research funding from Liaoning Provincial Natural Science Foundation; Yong-Feng Yuan is an employee of Harbin Institute of Technology; Shu-Mei Shan owns stocks and/or shares in Dalian Mingsheng Technology Development Company; Jin-Hua Liu and Dan-Yang Liu owns patent Built-in Straw type small intestine endoscope: China, 200920351611.5 [P]. 2010-09-08; and Catheter balloon type small intestine endoscope: China, 200920351612.X [P]. 2010-09-08.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at URL. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Jun Sun, PhD, Full Professor, Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi’an 710061, Shaanxi Province, China. sunxy@mail.xjtu.edu.cn
Received: October 11, 2021
Peer-review started: October 11, 2021
First decision: November 15, 2021
Revised: November 29, 2021
Accepted: February 23, 2022
Article in press: February 23, 2022
Published online: April 7, 2022
Processing time: 170 Days and 4.8 Hours
Abstract
BACKGROUND

Small intestine disease endangers human health and is not easy to locate and diagnose.

AIM

To observe the effect of the MS series of small intestine endoscopes on the gastrointestinal tract, the changes in serum gastrin levels and intestinal tissue, and the time required for the examination.

METHODS

In vivo experiments in 20 Living pigs were conducted, Bowel preparation was routinely performed, Intravenous anesthesia with propofol and ketamine was applied, the condition of the small intestine was observed and the detection time of the MS series of small intestine endoscopes were recorded, The changes in intestinal tissue using the MS series of small intestine endoscopes observed and compared before and after the examination, Venous blood (3-5 mL) from pigs was collected before and after the experiment; changes in intestinal tissue after use of the MS series of small intestine endoscopes observed after examination. After completion of each type of small intestine endoscope experiment, the pigs were allowed to rest and the next type of small intestine endoscope experiment was performed after 15 days of normal feeding. The detection time data of the single-balloon small intestine endoscope and double-balloon small intestine endoscope were collected from four hospitals.

RESULTS

One case of Ascarislumbricoides, one of suspected Crohn's disease, one small intestinal diverticulum and one anesthesia accident were observed in pigs. The small intestine showed no differences in the MS series of small intestine endoscopes and there were no differences in serum gastrin between the groups (P > 0.05). The time required for inspection was recorded, and the overall detection time for the Japanese small intestine endoscopes was approximately 1.68 ± 0.16 h.

CONCLUSION

Intestinal ascariasis is a common disease in pigs. Some pigs have abnormal intestinal variation. After continuous upgrade and improvement, the MS-3 and MS-4 small intestine endoscope appear superior in terms of detection time.

Keywords: Intestinal ascariasis; Intestinal variation; Crohn's disease; Serum gastrin; Small intestine endoscope

Core Tip: There are many types of hormones and their contents are extremely small (mostly in the range of nanograms and even picograms).They are neither the energy source of the body nor structural substances of the human body. However, they play essential roles in coordinating physiological processes such as metabolism and growth/development by transmitting information. Research on the changes in gastrin before and after the use of MS series of small intestine endoscope can provide theoretical support for the safe application of small intestine endoscopes.