Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model

doi:10.3748/wjg.v27.i47.8194

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Dec 21, 2021; 27(47): 8194-8198
Published online Dec 21, 2021. doi: 10.3748/wjg.v27.i47.8194

Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model

Deng-Hai Mi, Xiao-Long Tang, Jiang-Tao Wang, Yan-Dong Miao

Yan-Dong Miao, Jiang-Tao Wang, Xiao-Long Tang, Deng-Hai Mi, The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, China

Deng-Hai Mi, Dean's office, Gansu Academy of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China

Author contributions: Mi DH and Miao YD designed the research; Miao YD wrote this comment; Wang JT and Tang XL made academic advice; Mi DH reviewed this manuscript; all authors approved the final manuscript.

Conflict-of-interest statement: No conflict of interest associated with any of the senior authors or other coauthors contributed their efforts in this manuscript.

Corresponding author: Yan-Dong Miao, MD, Doctor, The First Clinical Medical College, Lanzhou University, No. 1 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. miaoyd19@lzu.edu.cn

Received: June 22, 2021
Peer-review started: June 22, 2021
First decision: July 4, 2021
Revised: July 6, 2021
Accepted: December 2, 2021
Article in press: December 2, 2021
Published online: December 21, 2021
Processing time: 177 Days and 23.1 Hours

Abstract

CXCL12 expression was significantly lower in tumor samples than in corresponding normal samples. CXCL12 expression was significantly positively related to the infiltration levels of T cells, dendritic cells (DCs), immature DCs, cytotoxic cells, Tfh cells, mast cells, B cells, Th1 cells, natural killer (NK) cells, pDCs, neutrophils, and T helper cells (Spearman correlation coefficient > 0.5, P < 0.001) and negatively correlated with the infiltration level of NK CD56bright cells. In addition, pancreatic hTERT-HPNE cells treated with three diverse CXCL12 isoforms exhibited changes mainly in the regulation of the epithelial-mesenchymal transition activation pathway.

Keywords: CXCL12; Pancreatic cancer; Splicing isoforms; Bioinformatics analysis; Tumor microenvironment; Pathway

Core Tip: CXCL12 expression was significantly lower in tumor samples than in normal samples. CXCL12 expression was significantly positively associated with the infiltration levels of 12 immune cells, especially T cells, which may encourage further exploration of the effect of CXCL12 in pancreatic ductal adenocarcinoma immunotherapy. In addition, treating pancreatic hTERT-HPNE cells with three diverse CXCL12 isoforms mainly affected the regulation of the epithelial-mesenchymal transition activation pathway.