Di Sessa A, Guarino S, Melone R, De Simone RF, Marzuillo P, Miraglia del Giudice E. Relationship between nonalcoholic fatty liver disease and chronic kidney disease could start in childhood. World J Gastroenterol 2021; 27(34): 5793-5795 [PMID: 34629802 DOI: 10.3748/wjg.v27.i34.5793]
Corresponding Author of This Article
Pierluigi Marzuillo, MD, PhD, Assistant Professor, Department of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Via de Crecchio, Naples 80138, Italy. pierluigi.marzuillo@gmail.com
Research Domain of This Article
Pediatrics
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Sep 14, 2021; 27(34): 5793-5795 Published online Sep 14, 2021. doi: 10.3748/wjg.v27.i34.5793
Relationship between nonalcoholic fatty liver disease and chronic kidney disease could start in childhood
Anna Di Sessa, Stefano Guarino, Rosa Melone, Rossella Francesca De Simone, Pierluigi Marzuillo, Emanuele Miraglia del Giudice
Anna Di Sessa, Stefano Guarino, Rosa Melone, Rossella Francesca De Simone, Pierluigi Marzuillo, Emanuele Miraglia del Giudice, Department of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples 80138, Italy
Author contributions: Di Sessa A wrote the letter; Di Sessa A, Miraglia del Giudice E and Marzuillo P conceived the manuscript; Miraglia del Giudice E supervised the manuscript drafting; Guarino S, Melone R and De Simone RF reviewed the literature data; each author contributed important intellectual content during manuscript drafting or revision.
Conflict-of-interest statement: Nothing to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pierluigi Marzuillo, MD, PhD, Assistant Professor, Department of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Via de Crecchio, Naples 80138, Italy. pierluigi.marzuillo@gmail.com
Received: May 4, 2021 Peer-review started: May 4, 2021 First decision: June 12, 2021 Revised: June 21, 2021 Accepted: August 6, 2021 Article in press: August 6, 2021 Published online: September 14, 2021 Processing time: 127 Days and 8.5 Hours
Abstract
The relationship between nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) has gained considerable scientific interest in adults over the past few years. However, this association has recently emerged in children. Several published studies have suggested a role for NAFLD as a risk factor for CKD from the earliest age, with a potential influence of the major NAFLD risk polymorphisms, resulting in an increased risk of both cardiovascular and metabolic diseases. In view of the progressive course and increased cardiometabolic risk closely related to NAFLD and CKD, we focused on the link between these diseases in childhood.
Core Tip: Nonalcoholic fatty liver disease has been linked to chronic kidney disease in childhood. Due to the intrinsic cardiometabolic burden related to both diseases, we highlighted the importance of knowledge of this relationship in pediatric patients.
