Published online Sep 14, 2020. doi: 10.3748/wjg.v26.i34.5220
Peer-review started: May 22, 2020
First decision: June 4, 2020
Revised: June 11, 2020
Accepted: August 26, 2020
Article in press: August 26, 2020
Published online: September 14, 2020
Processing time: 109 Days and 13.5 Hours
Peliosis hepatis is a rare benign disease, but in last years the number of identified cases has increased. This disease is known to be sometimes accompanied by hepatocellular carcinoma. In the recent article, Yu et al describe a case of liver peliosis, characterized by an increased proliferative index. Therefore, additional diagnosis of patients should include analyzing other tumor markers expression in order to assess the risk of malignant cell transformation in peliosis hepatis.
Core Tip: Peliosis hepatis may be accompanied by malignant transformation. However, it remains unclear whether there is a pathogenetic relationship between these two conditions. The major purpose of this letter is to draw attention to the problem of timely diagnosis of carcinogenesis and prevention of tumor progression against the background of peliosis.