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World J Gastroenterol. Apr 7, 2019; 25(13): 1560-1565
Published online Apr 7, 2019. doi: 10.3748/wjg.v25.i13.1560
Cellular therapy: A promising tool in the future of colorectal surgery
Mohammed Mohammed El-Said, Sameh Hany Emile
Mohammed Mohammed El-Said, Sameh Hany Emile, Colorectal Surgery Unit, General Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura 35516, Egypt
Author contributions: El-Said MM and Emile SH designed, wrote, and revised the manuscript.
Conflict-of-interest statement: All authors declare no conflicts-of-interest related to this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Sameh Hany Emile, MBChB, MD, MSc, Lecturer, Surgeon, Colorectal Surgery Unit, General Surgery Department, Mansoura University Hospitals, Mansoura University, Dakahlia Governorate, Mansoura 35516, Egypt. sameh200@hotmail.com
Telephone: +20-1006267150 Fax: +20-50-239733
Received: January 8, 2019
Peer-review started: January 8, 2019
First decision: February 13, 2019
Revised: February 28, 2019
Accepted: March 1, 2019
Article in press: March 2, 2019
Published online: April 7, 2019
Processing time: 86 Days and 5.6 Hours
Abstract

Cellular therapy may be the solution of challenging problems in colorectal surgery such as impaired healing leading to anastomotic leakage and metastatic colorectal cancer (CRC). This review aimed to illustrate the role of cellular therapy in promotion of wound healing and management of metastatic CRC. An organized literature search for the role of cellular therapy in promotion of wound healing and management of metastatic CRC was conducted. Electronic databases including PubMed/Medline, Scopus, and Embase were queried for the search process. Two types of cellular therapy have been recognized, the mesenchymal stem cells (MSCs) and bone marrow-mononuclear cells (BM-MNCs) therapy. These cells have been shown to accelerate and promote healing of various tissue injuries in animal and human studies. In addition, experimental studies have reported that MSCs may help suppress the progression of colon cancer in rat models. This article reviews the possible mechanisms of action and clinical utility of MSCs and BM-MNCs in promotion of healing and suppression of tumor growth in light of the published literature. Cellular therapy has a potentially important role in colorectal surgery, particularly in the promotion of wound healing and management of metastatic CRC. Future directions of cellular therapy in colorectal surgery were explored which may help stimulate futures studies on the role of cellular therapy in colorectal surgery.

Keywords: Cellular therapy; Future; Colorectal surgery; Stem cells

Core tip: Cellular therapy may be the solution of challenging problems in colorectal surgery such as impaired healing leading to anastomotic leakage and metastatic colorectal cancer. Two types of cellular therapy have been recognized, the mesenchymal stem cells (MSCs) and bone marrow-mononuclear cells therapy. These cells have been shown to accelerate and promote healing of various tissue injuries in animal and human studies. In addition, experimental studies have reported that MSCs may help suppress the progression of colon cancer in rat models.