Cheng JL, Cui J, Wang Y, Xu ZZ, Liu F, Liang SB, Tian H. Unicentric Castleman disease presenting as a retroperitoneal peripancreatic mass: A report of two cases and review of literature. World J Gastroenterol 2018; 24(34): 3958-3964 [PMID: 30228787 DOI: 10.3748/wjg.v24.i34.3958]
Corresponding Author of This Article
Hu Tian, MD, PhD, Chief Doctor, Professor, Surgeon, Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, No. 16766, Jingshi Road, Jinan 250014, Shandong Province, China. tianhu6585@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Sep 14, 2018; 24(34): 3958-3964 Published online Sep 14, 2018. doi: 10.3748/wjg.v24.i34.3958
Unicentric Castleman disease presenting as a retroperitoneal peripancreatic mass: A report of two cases and review of literature
Jia-Lin Cheng, Jing Cui, Yi Wang, Zong-Zhen Xu, Feng Liu, Shu-Bin Liang, Hu Tian
Jia-Lin Cheng, Shu-Bin Liang, Taishan Medical University, Tai’an 271016, Shandong Province, China
Jia-Lin Cheng, Zong-Zhen Xu, Feng Liu, Shu-Bin Liang, Hu Tian, Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China
Jing Cui, Department of Pathology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China
Yi Wang, Department of Medical Imaging, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China
Author contributions: Cheng JL designed the report and wrote the paper; Cheng JL, Xu ZZ, Liu F and Tian H performed the surgery; Cheng JL, Cui J, Wang Y and Liang SB collected the patient’s clinical data; Cheng JL and Tian H analyzed the data and revised the paper; all authors have read and approved the final version of this manuscript.
Supported bythe Key Research and Development Plan of Shandong Province, No. 2016GSF201108.
Informed consent statement: The patients included in this study gave written informed consent for the use and disclosure of their protected health information.
Conflict-of-interest statement: The authors of this manuscript have no conflicts of interest to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hu Tian, MD, PhD, Chief Doctor, Professor, Surgeon, Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, No. 16766, Jingshi Road, Jinan 250014, Shandong Province, China. tianhu6585@163.com
Telephone: +86-531-89269817 Fax: +86-531-82963647
Received: April 23, 2018 Peer-review started: April 27, 2018 First decision: July 4, 2018 Revised: July 10, 2018 Accepted: July 22, 2018 Article in press: July 22, 2018 Published online: September 14, 2018 Processing time: 145 Days and 13 Hours
Abstract
Castleman disease (CD) is a rare disorder of lymph nodes and related tissues. CD generally occurs in the mediastinum, as well as in cervical, retroperitoneal and axillary regions. The disease is classified into two major types: unicentric CD (UCD) and multicentric CD. The occurrence of UCD in the retroperitoneal peripancreatic region is quite rare. We encountered two cases of retroperitoneal peripancreatic UCD in our hospital during the past three years. Following a series of medical examinations, including magnetic resonance imaging, computed tomography, ultrasonography and postoperative histopathological examination, these two patients were diagnosed with UCD, which presented as a retroperitoneal peripancreatic mass. The mass in each patient was completely excised, and no postoperative radiochemotherapy was administered. Both patients recovered well without recurrence during a follow-up period of 30 mo and 8 mo.
Core tip: We report two typical cases of unicentric Castleman disease (UCD) presenting as a retroperitoneal peripancreatic mass. The clinical manifestations and imaging findings of these masses were nonspecific. UCD is difficult to diagnose prior to surgery, and the diagnosis is mainly by postoperative pathological examination. The occurrence of UCD in the abdominal cavity is very rare, especially in the retroperitoneal peripancreatic region. Importantly, both patients recovered well without postoperative radiochemotherapy. These case reports provide a valuable reference for the diagnosis and treatment of this disease.
