Ibarra A, Olli K, Ouwehand AC. Correcting for non-compliance when determining colonic transit time with radio-opaque markers. World J Gastroenterol 2017; 23(4): 740-742 [PMID: 28216983 DOI: 10.3748/wjg.v23.i4.740]
Corresponding Author of This Article
Alvin Ibarra, PhD, DuPont Nutrition and Health, Danisco Sweeteners Oy, Sokeritehtaantie 20, 02460 Kantvik, Finland. alvin.ibarra@dupont.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letters To The Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jan 28, 2017; 23(4): 740-742 Published online Jan 28, 2017. doi: 10.3748/wjg.v23.i4.740
Correcting for non-compliance when determining colonic transit time with radio-opaque markers
Alvin Ibarra, Kaisa Olli, Arthur C Ouwehand
Alvin Ibarra, Kaisa Olli, Arthur C Ouwehand, DuPont Nutrition and Health, 02460 Kantvik, Finland
Author contributions: Ibarra A, Olli K and Ouwehand AC wrote this letter.
Conflict-of-interest statement: Alvin Ibarra, Kaisa Olli and Arthur C Ouwehand were employees of DuPont during the preparation of the Letter to the Editor and declare no other conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Alvin Ibarra, PhD, DuPont Nutrition and Health, Danisco Sweeteners Oy, Sokeritehtaantie 20, 02460 Kantvik, Finland. alvin.ibarra@dupont.com
Telephone: +358-40-1678509 Fax: +358-40-1678509
Received: October 7, 2016 Peer-review started: October 9, 2016 First decision: October 28, 2016 Revised: November 10, 2016 Accepted: December 8, 2016 Article in press: December 8, 2016 Published online: January 28, 2017 Processing time: 103 Days and 16.9 Hours
Abstract
The use of radio-opaque markers and abdominal X-ray is the standard method for determining colonic transit time (CTT). However, when there are deviations in the intake of these markers by participants in clinical trials it is desirable to improve observations by introducing corrections, where possible. To date, there is no standard procedure to adjust for such deviations. This report proposes a series of alternatives based on possible scenarios for deviations from the intended intake of radio-opaque markers. The proposed method to correct for missed or delayed consumption of radio-opaque markers can help to increase the accuracy of the CTT measurements in clinical trials.
