Kim JH, Lee JY, Kim HK, Lee JW, Jung SG, Jung K, Kim SE, Moon W, Park MI, Park SJ. Prognostic significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with stage III and IV colorectal cancer. World J Gastroenterol 2017; 23(3): 505-515 [PMID: 28210087 DOI: 10.3748/wjg.v23.i3.505]
Corresponding Author of This Article
Seun Ja Park, MD, Division of Gastroenterology, Department of Internal Medicine, Kosin University College of Medicine, 34 Amnam-dong, Seo-gu, Busan 602-702, South Korea. parksj6406@daum.net
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jan 21, 2017; 23(3): 505-515 Published online Jan 21, 2017. doi: 10.3748/wjg.v23.i3.505
Prognostic significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with stage III and IV colorectal cancer
Jae Hyun Kim, Jun Yeop Lee, Hae Koo Kim, Jin Wook Lee, Sung Gyu Jung, Kyoungwon Jung, Sung Eun Kim, Won Moon, Moo In Park, Seun Ja Park
Jae Hyun Kim, Jun Yeop Lee, Hae Koo Kim, Jin Wook Lee, Sung Gyu Jung, Kyoungwon Jung, Sung Eun Kim, Won Moon, Moo In Park, Seun Ja Park, Division of Gastroenterology, Department of Internal Medicine, Kosin University College of Medicine, Busan 602-702, South Korea
Author contributions: Kim JH and Park SJ designed study; Kim JH wrote the paper; Lee JY, Kim HK, Lee JW, Jung K, Kim SE, Moon W and Park MI critically reviewed the manuscript for important intellectual content; and Park SJ approved the manuscript; all the authors contributed to this manuscript.
Institutional review board statement: This is to certify that the information contained herein is true and correct as reflected in the records of the KUGH lRB. We certify that KUGH IRB is in full complicance with good clinical practice as defined under Ministry of Food and Drug Safety (MFDS) regulations and the International Conference on Harmonization (lCH) guidelines.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Seun Ja Park, MD, Division of Gastroenterology, Department of Internal Medicine, Kosin University College of Medicine, 34 Amnam-dong, Seo-gu, Busan 602-702, South Korea. parksj6406@daum.net
Telephone: +82-51-9905061 Fax: +82-51-9905055
Received: October 25, 2016 Peer-review started: October 26, 2016 First decision: December 1, 2016 Revised: December 5, 2016 Accepted: December 21, 2016 Article in press: December 21, 2016 Published online: January 21, 2017 Processing time: 80 Days and 15.6 Hours
Abstract
AIM
To evaluate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC).
METHODS
Between April 1996 and December 2010, medical records from a total of 1868 patients with CRC were retrospectively reviewed. The values of simple inflammatory markers including NLR and PLR in predicting the long-term outcomes of these patients were evaluated using Kaplan-Meier curves and Cox regression models.
RESULTS
The median follow-up duration was 46 mo (interquartile range, 22-73). The estimation of NLR and PLR was based on the time of diagnosis. In multivariate Cox regression analysis, high NLR (≥ 3.0) and high PLR (≥ 160) were independent risk factors predicting poor long-term outcomes in patients with stage III and IV CRC. However, high NLR and high PLR were not prognostic factors in patients with stage I and II CRC.
CONCLUSION
In this study, we identified that high NLR (≥ 3.0) and high PLR (≥ 160) are useful prognostic factors to predict long-term outcomes in patients with stage III and IV CRC.
Core tip: Recently, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been suggested as important inflammatory markers and potential predictors of long-term outcomes in patients with colorectal cancer (CRC). However, the direct impact of NLR and PLR on long-term outcomes in patients with CRC remains inconclusive. In this study, we identified that high NLR and high PLR are useful independent prognostic factors to predict poor long-term outcomes in patients with stage III and IV CRC. And we propose that initial assessment of NLR and PLR in newly diagnosed stage III and IV CRC patients is important for predicting long-term outcomes.
