Triki M, Lapierre M, Cavailles V, Mokdad-Gargouri R. Expression and role of nuclear receptor coregulators in colorectal cancer. World J Gastroenterol 2017; 23(25): 4480-4490 [PMID: 28740336 DOI: 10.3748/wjg.v23.i25.4480]
Corresponding Author of This Article
Vincent Cavaillès, PhD, IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, 208 rue des apothicaires, 34298 Montpellier, France. vincent.cavailles@inserm.fr
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Biochemistry & Molecular Biology
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Review
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Triki M, Lapierre M, Cavailles V, Mokdad-Gargouri R. Expression and role of nuclear receptor coregulators in colorectal cancer. World J Gastroenterol 2017; 23(25): 4480-4490 [PMID: 28740336 DOI: 10.3748/wjg.v23.i25.4480]
World J Gastroenterol. Jul 7, 2017; 23(25): 4480-4490 Published online Jul 7, 2017. doi: 10.3748/wjg.v23.i25.4480
Expression and role of nuclear receptor coregulators in colorectal cancer
Mouna Triki, Marion Lapierre, Vincent Cavailles, Raja Mokdad-Gargouri
Mouna Triki, Marion Lapierre, Vincent Cavailles, IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, 34298 Montpellier, France
Mouna Triki, Raja Mokdad-Gargouri, Centre de Biotechnologie de Sfax, Université de Sfax, Sfax 3072, Tunisie
Author contributions: Triki M performed the literature review and analysis, wrote the manuscript and contributed to the generation of figures; Lapierre M and Mokdad-Gargouri R contributed to the drafting, editing and critical revision of the manuscript; Cavailles V designed the aim of the review, generated the figures and wrote the manuscript; all authors approved the final version.
Supported bySIRIC and the PHC-UTIQUE program, No. 16G 0805; PHC-UTIQUE program, No. 16G 0805; Tunisian government (Bourse d’alternance); INSERM, Université de Montpellier, INCa, SIRIC Montpellier, the Institut régional du Cancer de Montpellier.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Correspondence to: Vincent Cavaillès, PhD, IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, 208 rue des apothicaires, 34298 Montpellier, France. vincent.cavailles@inserm.fr
Telephone: +33-4-67612405 Fax: +33-4-67613787
Received: August 2, 2016 Peer-review started: August 3, 2016 First decision: September 5, 2016 Revised: September 30, 2016 Accepted: October 31, 2016 Article in press: October 31, 2016 Published online: July 7, 2017 Processing time: 338 Days and 11.9 Hours
Abstract
Colorectal cancer (CRC) is one of the most common human cancers and the cause of about 700000 deaths per year worldwide. Deregulation of the WNT/β-catenin pathway is a key event in CRC initiation. This pathway interacts with other nuclear signaling pathways, including members of the nuclear receptor superfamily and their transcription coregulators. In this review, we provide an overview of the literature dealing with the main coactivators (NCoA-1 to 3, NCoA-6, PGC1-α, p300, CREBBP and MED1) and corepressors (N-CoR1 and 2, NRIP1 and MTA1) of nuclear receptors and summarize their links with the WNT/β-catenin signaling cascade, their expression in CRC and their role in intestinal physiopathology.
Core tip: Colorectal cancer (CRC) is one of the most common human cancers worldwide. Deregulation of the WNT/β-catenin pathway is a key event in CRC initiation. This pathway interacts with other nuclear signaling pathways, including members of the nuclear receptor superfamily and their transcription coregulators. In this review, we provide an overview of the literature dealing with the main coactivators and corepressors of nuclear receptors, and summarize their links with the WNT/β-catenin signaling cascade, their expression in CRC and their role in intestinal physiopathology.
