Zheng SM, Zhou DJ, Chen YH, Jiang R, Wang YX, Zhang Y, Xue HL, Wang HQ, Mou D, Zeng WZ. Pancreatic T/histiocyte-rich large B-cell lymphoma: A case report and review of literature. World J Gastroenterol 2017; 23(24): 4467-4472 [PMID: 28706431 DOI: 10.3748/wjg.v23.i24.4467]
Corresponding Author of This Article
Wei-Zheng Zeng, MD, Director, Department of Gastroenterology and Hepatology, Chengdu Military General Hospital, 270 Rongdu Road, Chengdu 610083, Sichuan Province, China. zengweizheng@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Zheng SM, Zhou DJ, Chen YH, Jiang R, Wang YX, Zhang Y, Xue HL, Wang HQ, Mou D, Zeng WZ. Pancreatic T/histiocyte-rich large B-cell lymphoma: A case report and review of literature. World J Gastroenterol 2017; 23(24): 4467-4472 [PMID: 28706431 DOI: 10.3748/wjg.v23.i24.4467]
Shu-Mei Zheng, De-Jiang Zhou, Yun-Xia Wang, Yong Zhang, Hong-Li Xue, Hai-Qiong Wang, Dong Mou, Wei-Zheng Zeng, Department of Gastroenterology and Hepatology, Chengdu Military General Hospital, Chengdu 610083, Sichuan Province, China
Yi-Hua Chen, Department of Pathology, Chengdu Military General Hospital, Chengdu 610083, Sichuan Province, China
Rui Jiang, Department of Radiology, Chengdu Military General Hospital, Chengdu 610083, Sichuan Province, China
Author contributions: Zheng SM and Zhou DJ contributed equally to this work; Zheng SM and Zeng WZ designed the report; Wang YX, Zhang Y, Xue HL, Wang HQ and Mou D collected the patient’s clinical data; Chen YH provided and analyzed the microscopy images; Jiang R provided and analyzed the CT scan images; Zheng SM and Zhou DJ wrote the paper; all authors have read and approved the final version to be published.
Institutional review board statement: This case report was approved by the Institutional Review Board standards at Chengdu Military General Hospital.
Informed consent statement: The patient gave informed consent for the study.
Conflict-of-interest statement: Authors have no conflict of interest to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Wei-Zheng Zeng, MD, Director, Department of Gastroenterology and Hepatology, Chengdu Military General Hospital, 270 Rongdu Road, Chengdu 610083, Sichuan Province, China. zengweizheng@163.com
Telephone: +86-28-86571145 Fax: +86-28-86571145
Received: March 18, 2017 Peer-review started: March 19, 2017 First decision: April 11, 2017 Revised: April 26, 2017 Accepted: June 1, 2017 Article in press: June 1, 2017 Published online: June 28, 2017 Processing time: 100 Days and 0.2 Hours
Abstract
Primary pancreatic lymphoma (PPL) is an extremely rare form of extranodal malignant lymphoma. The most common histological subtype of PPL is diffuse large B cell lymphoma (DLBCL). In rare cases, PPL can also present as follicular lymphoma, small lymphocytic lymphoma, and T cell lymphoma either of non-Hodgkin’s lymphoma or of Hodgkin’s lymphoma. T-cell/histiocyte-rich large B-cell lymphoma (T/HRBCL) is an uncommon morphologic variant of DLBCL with aggressive clinical course, it is predominantly a nodal disease, but extranodal sites such as bone marrow, liver, and spleen can be involved. Pancreatic involvement of T/HRBCL was not presented before. Herein, we report a 48-year-old male who was hospitalized with complaints of jaundice, dark brown urine, pale stools, and nausea. The radiological evaluation revealed a pancreatic head mass and, following operative biopsy, the tumor was diagnosed as T/HRBCL. The patient achieved remission after six cycles of CHOP chemotherapy. Therefore, T/HRBCL can be treated similarly to the stage-matched DLBCL and both of them get equivalent outcomes after chemotherapy.
Core tip: T-cell/histiocyte-rich large B-cell lymphoma (T/HRBCL) is an uncommon morphologic variant of diffuse large B cell lymphoma. Pancreatic T/HRBCL has not been reported to date. Here, we present the first case of a patient diagnosed with pancreatic T/HRBCL who was successfully treated with systemic chemotherapy.
