Liu T, Zhong MW, Liu Y, Huang X, Cheng YG, Wang KX, Liu SZ, Hu SY. Effects of sleeve gastrectomy plus trunk vagotomy compared with sleeve gastrectomy on glucose metabolism in diabetic rats. World J Gastroenterol 2017; 23(18): 3269-3278 [PMID: 28566886 DOI: 10.3748/wjg.v23.i18.3269]
Corresponding Author of This Article
San-Yuan Hu, Professor, Department of General Surgery, Qilu Hospital of Shandong University, No. 107, Wenhua Xi Road, Jinan 250012, Shandong Province, China. husanyuan1962@hotmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
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Liu T, Zhong MW, Liu Y, Huang X, Cheng YG, Wang KX, Liu SZ, Hu SY. Effects of sleeve gastrectomy plus trunk vagotomy compared with sleeve gastrectomy on glucose metabolism in diabetic rats. World J Gastroenterol 2017; 23(18): 3269-3278 [PMID: 28566886 DOI: 10.3748/wjg.v23.i18.3269]
World J Gastroenterol. May 14, 2017; 23(18): 3269-3278 Published online May 14, 2017. doi: 10.3748/wjg.v23.i18.3269
Effects of sleeve gastrectomy plus trunk vagotomy compared with sleeve gastrectomy on glucose metabolism in diabetic rats
Teng Liu, Ming-Wei Zhong, Yi Liu, Xin Huang, Yu-Gang Cheng, Ke-Xin Wang, Shao-Zhuang Liu, San-Yuan Hu
Teng Liu, Ming-Wei Zhong, Xin Huang, Yu-Gang Cheng, Ke-Xin Wang, Shao-Zhuang Liu, San-Yuan Hu, Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Yi Liu, Health and Family Planning Commission of Shandong Provincial Medical Guidance Center, Jinan 250012, Shandong Province, China
Author contributions: Liu T, Liu SZ and Hu SY designed the study and wrote the manuscript; Liu T and Zhong MW instructed on the whole study and prepared the figures; Liu Y and Wang KX collected and analyzed the data; Liu T, Huang X and Cheng YG performed the operations and performed the observational study; Huang X and Cheng YG performed the molecular investigations; all authors have approved the final version to be published.
Supported byNational Natural Science Foundation of China, No. 81471019 (to Hu SY) and No. 81300286 (to Liu SZ); Foundation for Outstanding Young Scientist in Shandong Province, No. BS2013YY031 (to Liu SZ); Science and Technology Development Program of Shandong Province, No. 2014GGE27485 (to Liu SZ); Specialized Research Fund for the Doctoral Program of Higher Education of China, No. 20130131120069 (to Liu SZ).
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Qilu Hospital of Shandong University, Jinan, China.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Ethics Committee on Animal Experiment of Shandong University Qilu Hospital (IACUC protocol number: DWLL-2015-014).
Conflict-of-interest statement: All authors have no conflict of interest related to the manuscript.
Data sharing statement: No additional data are available.
Correspondence to: San-Yuan Hu, Professor, Department of General Surgery, Qilu Hospital of Shandong University, No. 107, Wenhua Xi Road, Jinan 250012, Shandong Province, China. husanyuan1962@hotmail.com
Telephone: +86-531-82166351 Fax: +86-531-86920598
Received: January 20, 2017 Peer-review started: January 20, 2017 First decision: February 9, 2017 Revised: April 25, 2017 Accepted: May 4, 2017 Article in press: May 4, 2017 Published online: May 14, 2017 Processing time: 114 Days and 14.4 Hours
Abstract
AIM
To investigate the effects of sleeve gastrectomy plus trunk vagotomy (SGTV) compared with sleeve gastrectomy (SG) in a diabetic rat model.
METHODS
SGTV, SG, TV and Sham operations were performed on rats with diabetes induced by high-fat diet and streptozotocin. Body weight, food intake, oral glucose tolerance test, homeostasis model assessment of insulin resistance (HOMA-IR), hepatic insulin signaling (IR, IRS1, IRS2, PI3K and AKT), oral glucose stimulated insulin secretion, GLP-1 and ghrelin were compared at various postoperative times.
RESULTS
Both SG and SGTV resulted in better glucose tolerance, lower HOMA-IR, up-regulated hepatic insulin signaling, higher levels of oral glucose-stimulated insulin secretion, higher postprandial GLP-1 and lower fasting ghrelin levels than the TV and Sham groups. No significant differences were observed between the SG and SGTV groups. In addition, no significant differences were found between the TV and Sham groups in terms of glucose tolerance, HOMA-IR, hepatic insulin signaling, oral glucose-stimulated insulin secretion, postprandial GLP-1 and fasting ghrelin levels. No differences in body weight and food intake were noted between the four groups.
CONCLUSION
SGTV is feasible for diabetes control and is independent of weight loss. However, SGTV did not result in a better improvement in diabetes than SG alone.
Core tip: To investigate the effects of sleeve gastrectomy plus trunk vagotomy (SGTV) compared with sleeve gastrectomy (SG) in a diabetic rat model, SGTV, SG, TV and Sham operations were performed on diabetic rats. The result showed that SG and SGTV resulted in better glucose regulation, but SGTV did not result in a better improvement in diabetes than SG alone.
