Lai CC, Ho CH, Cheng KC, Chao CM, Chen CM, Chou W. Effect of liver cirrhosis on long-term outcomes after acute respiratory failure: A population-based study. World J Gastroenterol 2017; 23(12): 2201-2208 [PMID: 28405148 DOI: 10.3748/wjg.v23.i12.2201]
Corresponding Author of This Article
Chin-Ming Chen, MD, Department of Intensive Care Medicine, Chi Mei Medical Center, 901 Zhonghua Road, Yongkang Dist., Tainan 710, Taiwan. chencm3383@yahoo.com.tw
Research Domain of This Article
Critical Care Medicine
Article-Type of This Article
Retrospective Cohort Study
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Lai CC, Ho CH, Cheng KC, Chao CM, Chen CM, Chou W. Effect of liver cirrhosis on long-term outcomes after acute respiratory failure: A population-based study. World J Gastroenterol 2017; 23(12): 2201-2208 [PMID: 28405148 DOI: 10.3748/wjg.v23.i12.2201]
Chih-Cheng Lai, Chien-Ming Chao, Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan 736, Taiwan
Chung-Han Ho, Departments of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan
Kuo-Chen Cheng, Internal Medicine, Chi Mei Medical Center, Tainan 710, Taiwan
Kuo-Chen Cheng, Department of Safety, Health and Environment, Chung Hwa University of Medical Technology, Tainan 717, Taiwan
Chin-Ming Chen, Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan 710, Taiwan
Chin-Ming Chen, Willy Chou, Department of Recreation and Health-Care Management, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan
Author contributions: Chen CM is the guarantor of this manuscript; Lai CC, Ho CH, Cheng KC, Chao CM and Chou W contributed to the conception and design of the study; Ho CH analyzed and interpreted the data; Lai CC and Chen CM drafted the manuscript.
Institutional review board statement: The study was approved by the Institutional Review Board (IRB 10409-E04) at Chi Mei Medical Center.
Informed consent statement: Because the data used in this study have been deidentified and released to the public for research purposes, the need for informed consent from enrolled patients was waived by the Institutional Review Board at Chi Mei Medical Center.
Conflict-of-interest statement: All authors declared there is no conflict of interest.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author at chencm3383@yahoo.com.tw.
Correspondence to: Chin-Ming Chen, MD, Department of Intensive Care Medicine, Chi Mei Medical Center, 901 Zhonghua Road, Yongkang Dist., Tainan 710, Taiwan. chencm3383@yahoo.com.tw
Telephone: +886-6-2812811 Fax: +886-6-2812811
Received: December 23, 2016 Peer-review started: December 24, 2016 First decision: January 19, 2017 Revised: February 2, 2017 Accepted: March 2, 2017 Article in press: March 2, 2017 Published online: March 28, 2017 Processing time: 94 Days and 17.3 Hours
Abstract
AIM
To assessed the effect of liver cirrhosis (LC) on the poorly understood long-term mortality risk after first-ever mechanical ventilation (1-MV) for acute respiratory failure.
METHODS
All patients in Taiwan given a 1-MV between 1997 and 2013 were identified in Taiwan’s Longitudinal Health Insurance Database 2000. Each patient with LC was individually matched, using a propensity-score method, to two patients without LC. The primary outcome was death after a 1-MV.
RESULTS
A total of 16653 patients were enrolled: 5551 LC-positive (LC[Pos]) patients, including 1732 with cryptogenic LCs and 11102 LC-negative (LC[Neg]) controls. LC[Pos] patients had more organ failures and were more likely to be admitted to medical department than were LC[Neg] controls. LC[Pos] patients had a significantly lower survival rate (AHR = 1.38, 95%CI: 1.32-1.44). Moreover, the mortality risk was significantly higher for patients with non-cryptogenic LC than for patients with cryptogenic LC (AHR = 1.43, 95%CI: 1.32-1.54) and patients without LC (AHR = 1.56, 95%CI: 1.32-1.54). However, there was no significant difference between patients with cryptogenic and without LC (HR = 1.05, 95%CI: 0.98-1.12).
CONCLUSION
LC, especially non-cryptogenic LC, significantly increases the risk of death after a 1-MV.
