Validation of the chinese version of the EORTC QLQ-CR29 in patients with colorectal cancer

doi:10.3748/wjg.v23.i10.1891

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Mar 14, 2017; 23(10): 1891-1898
Published online Mar 14, 2017. doi: 10.3748/wjg.v23.i10.1891

Validation of the chinese version of the EORTC QLQ-CR29 in patients with colorectal cancer

Jin-Bo Lin, Lei Zhang, Dong-Wen Wu, Zhou-Huan Xi, Xue-Jun Wang, Yun-Shou Lin, Wakana Fujiwara, Jing-Ru Tian, Min Wang, Peng Peng, Ai Guo, Zhen Yang, Le Luo, Ling-Ya Jiang, Qia-Qia Li, Xue-Ying Zhang, Yun-Feng Zhang, Hou-Wei Xu, Bing Yang, Xun-Lin Li, Yi-Xiong Lei

Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China

Jin-Bo Lin, Bing Yang, Longgang Central Hospital of Shenzhen, Shenzhen 518116, Guangdong Province, China

Lei Zhang, Department of Thoracic Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Lung Cancer Center, Tianjin 300060, China

Dong-Wen Wu, Zhou-Huan Xi, Jing-Ru Tian, Zhen Yang, Ling-Ya Jiang, Qia-Qia Li, Xue-Ying Zhang, Xiangya School of Medicine, Central South University, Changsha 410013, Hunan Province, China

Xue-Jun Wang, Department of Gastrointestinal Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Lung Cancer Center, Tianjin 300060, China

Yun-Shou Lin, Min Wang, Peng Peng, Ai Guo, Xun-Lin Li, Tianjin Medical University, Tianjin 300060, China

Wakana Fujiwara, School of Medicine, Georgetown University, N.W., Washington D.C. 20057, United States

Le Luo, Department of Radiation Oncology, Tumor Hospital, Xiangya School of Medicine of Central South University, Changsha 410013, Hunan Province, China

Yun-Feng Zhang, Longgang District Peoples Hospital of Shenzhen, Shenzhen 518172, Guangdong Province, China

Hou-Wei Xu, Cancer Center of Guangzhou Medical University, Guangzhou 510182, Guangdong Province, China

Author contributions: Lin JB, Zhang L, Wu DW and Xi ZH designed the research; Wang XJ, Lin YS, Tian JR and Guo A performed data analysis and interpretation; Wang M and Peng P wrote the paper; Yang Z, Luo L, Jiang LY, Li QQ, Zhang XY, Zhang YF, Xu HW, Yang B and Li XL collected the data; Fujiwara W and Lei YX revised the article; all authors have approved the final version to be published.

Supported by Science & Technology Innovation Commission of Shenzhen (to Lin JB), No. 201404113000346 and No. JCYJ20140411150916744; and the Science & Technology Project of Shenzhen Longgang District, No. 201406063001007 and No. YLWS20140606101914846; and the Science & Technology Project of Shenzhen Longgang District, No. 20160607153104624 (to Zhang YF).

Institutional review board statement: The study was reviewed and approved by the Institutional Review Boards of the Third Xiangya Hospital of Central South University, the Affiliated Tumor Hospital of Central South University, the Longgang Central Hospital of Shenzhen, and the Affiliated Tumor Hospital of Guangzhou Medical University.

Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.

Conflict-of-interest statement: There is no conflict of interest related to this study.

Data sharing statement: The datasets in the current study are available from the corresponding author on reasonable request at colorectum@163.com.

Correspondence to: Yi-Xiong Lei, PhD, School of Public Health, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou 511436, Guangdong Province, China. colorectum@163.com

Telephone: +86-755-84802448 Fax: +86-755-84816979

Received: December 11, 2016
Peer-review started: December 12, 2016
First decision: December 29, 2016
Revised: January 19, 2017
Accepted: February 16, 2017
Article in press: February 17, 2017
Published online: March 14, 2017
Processing time: 92 Days and 8.3 Hours

Abstract

AIM

To assess the validity and reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal Cancer 29 (EORTC QLQ-CR29) in Chinese patients with colorectal cancer (CRC).

METHODS

From March 2014 to January 2015, 356 patients with CRC from four different hospitals in China were enrolled in the study, and all patients self-administered the EORTC QLQ-CR29 and the quality of life core questionnaire (EORTC QLQ-C30). Evaluation of the scores was based on the Karnofsky Performance Scale (KPS). The reliability and validity of the questionnaires were assessed by Cronbach’s α coefficient, the Spearman correlation test and Wilcoxon rank sum test.

RESULTS

The EORTC QLQ-CR29 showed satisfactory reliability (α > 0.7), although the urinary frequency and blood and mucus in stool dimensions had only moderate reliability (α = 0.608). The multitrait scaling analyses showed good convergent (r > 0.4) and discriminant validity. Significant differences were obtained for each item in the different KPS subgroups (KPS ≤ 80; KPS > 80). Body image and most single-item dimensions showed statistically significant differences in patients with a stoma compared with the rest of the patients.

CONCLUSION

The EORTC QLQ-CR29 exhibits high validity and reliability in Chinese patients with CRC, and can therefore be recommended as a valuable tool for the assessment of quality of life in these patients.

Keywords: Colorectal cancer; Health-related quality of life; EORTC QLQ-CR29; Mainland China

Core tip: This is the first study to examine the reliability and validity of the Chinese version of the EORTC QLQ-CR29 in patients with colorectal cancer in mainland China. The EORTC QLQ-CR29 exhibits high validity and reliability in Chinese patients with CRC, and can therefore be recommended as a valuable tool for the assessment of quality of life in these patients.