Grassi G, Di Caprio G, Fimia GM, Ippolito G, Tripodi M, Alonzi T. Hepatitis C virus relies on lipoproteins for its life cycle. World J Gastroenterol 2016; 22(6): 1953-1965 [PMID: 26877603 DOI: 10.3748/wjg.v22.i6.1953]
Corresponding Author of This Article
Tonino Alonzi, PhD, UOSD Gene Expression and Experimental Hepatology, National Institute for Infectious Diseases “L. Spallanzani” IRCCS. Via Portuense 292, 00149 Rome, Italy. tonino.alonzi@inmi.it
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Feb 14, 2016; 22(6): 1953-1965 Published online Feb 14, 2016. doi: 10.3748/wjg.v22.i6.1953
Hepatitis C virus relies on lipoproteins for its life cycle
Germana Grassi, Giorgia Di Caprio, Gian Maria Fimia, Giuseppe Ippolito, Marco Tripodi, Tonino Alonzi
Germana Grassi, Giorgia Di Caprio, Gian Maria Fimia, Giuseppe Ippolito, Marco Tripodi, Tonino Alonzi, National Institute for Infectious Diseases “L. Spallanzani” IRCCS, 00149 Rome, Italy
Giorgia Di Caprio, Marco Tripodi, Department of Cellular Biotechnologies and Hematology, Pasteur Institute-Cenci Bolognetti Foundation, Sapienza University of Rome, 00149 Rome, Italy
Gian Maria Fimia, Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, 73100 Lecce, Italy
Author contributions: All authors made substantial contributions to analysis and interpretation of data, drafting the article or making critical revisions related to important intellectual content; and gave final approval of the version of the article.
Supported by AIRC (to Tripodi M; No. IG-13529 to Fimia GM); Ministry for Health of Italy (“Ricerca Corrente” to Grassi G, Tripodi M, Alonzi T, Fimia GM and Ippolito G; “Ricerca Finalizzata” to Fimia GM and Ippolito G); Ministry of University and Research of Italy (PRIN to Tripodi M; PhD program to Di Caprio G).
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tonino Alonzi, PhD, UOSD Gene Expression and Experimental Hepatology, National Institute for Infectious Diseases “L. Spallanzani” IRCCS. Via Portuense 292, 00149 Rome, Italy. tonino.alonzi@inmi.it
Telephone: +39-6-55170909 Fax: +39-6-5582825
Received: August 25, 2015 Peer-review started: August 26, 2015 First decision: September 29, 2015 Revised: October 19, 2015 Accepted: December 19, 2015 Article in press: December 21, 2015 Published online: February 14, 2016 Processing time: 150 Days and 19.3 Hours
Abstract
Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence and pathogenesis are due to the ability of HCV to deregulate specific host processes, mainly lipid metabolism and innate immunity. In particular, HCV exploits the lipoprotein machineries for almost all steps of its life cycle. The aim of this review is to summarize current knowledge concerning the interplay between HCV and lipoprotein metabolism. We discuss the role played by members of lipoproteins in HCV entry, replication and virion production.
Core tip: The aim of the review is to summarize current knowledge concerning the interplay between hepatitis C virus (HCV) and lipoprotein metabolism. In particular, the manuscript discusses the role played by members of lipoproteins family in all steps of HCV life cycle.
