Lee MC, Ha W, Park J, Kim J, Jung Y, Kim BJ. Effects of Lizhong Tang on gastrointestinal motility in mice. World J Gastroenterol 2016; 22(34): 7778-7786 [PMID: 27678361 DOI: 10.3748/wjg.v22.i34.7778]
Corresponding Author of This Article
Byung Joo Kim, PhD, Associate Professor, Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Beomeori, Mulgeum-eup, Yangsan, Gyeongsangnamdo, 50612, South Korea. vision@pusan.ac.kr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Lee MC, Ha W, Park J, Kim J, Jung Y, Kim BJ. Effects of Lizhong Tang on gastrointestinal motility in mice. World J Gastroenterol 2016; 22(34): 7778-7786 [PMID: 27678361 DOI: 10.3748/wjg.v22.i34.7778]
World J Gastroenterol. Sep 14, 2016; 22(34): 7778-7786 Published online Sep 14, 2016. doi: 10.3748/wjg.v22.i34.7778
Effects of Lizhong Tang on gastrointestinal motility in mice
Min Cheol Lee, Wooram Ha, Jinhyeong Park, Junghoon Kim, Yunjin Jung, Byung Joo Kim
Min Cheol Lee, Byung Joo Kim, Division of Longevity and Biofunctional Medicine, Healthy Aging Korean Medical Research Center, School of Korean Medicine, Pusan National University, Yangsan 50612, South Korea
Wooram Ha, Jinhyeong Park, Junghoon Kim, Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan 50612, South Korea
Yunjin Jung, College of Pharmacy, Pusan National University, Busan 46241, South Korea
Author contributions: Lee MC and Kim BJ designed the research; Lee MC, Ha W, Park J and Kim J performed the experiments; Jung Y and Kim BJ analyzed the data; and Lee MC and Kim BJ wrote the paper.
Supported byNational Research Foundation of Korea Grant funded by the Korea Government, No. 2014R1A5A2009936.
Institutional animal care and use committee statement: Animal care and experiments were conducted in accordance with the guidelines issued by the Institutional Animal Care and Use Committee (IACUC) of Pusan National University (Busan, Republic of Korea; Approval No. PNU-2015-1036) and the Guide for the Care and Use of Laboratory Animals from the National Institutes of Health.
Conflict-of-interest statement: The authors declared that they have no conflicts of interest to this work.
Data sharing statement: No additional data are available.
Correspondence to: Byung Joo Kim, PhD, Associate Professor, Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Beomeori, Mulgeum-eup, Yangsan, Gyeongsangnamdo, 50612, South Korea. vision@pusan.ac.kr
Telephone: +82-51-5108469 Fax: +82-51-5108420
Received: May 2, 2016 Peer-review started: May 2, 2016 First decision: May 27, 2016 Revised: June 7, 2016 Accepted: July 31, 2016 Article in press: August 1, 2016 Published online: September 14, 2016 Processing time: 128 Days and 19 Hours
Abstract
AIM
To investigate the effects of Lizhong Tang, a traditional Chinese medicine formula, on gastrointestinal motility in mice.
METHODS
The in vivo effects of Lizhong Tang on GI motility were investigated by measuring the intestinal transit rates (ITRs) and gastric emptying (GE) values in normal mice and in mice with experimentally induced GI motility dysfunction (GMD).
RESULTS
In normal ICR mice, the ITR and GE values were significantly and dose-dependently increased by Lizhong Tang (ITR values: 54.4% ± 1.9% vs 65.2% ± 1.8%, P < 0.01 with 0.1 g/kg Lizhong Tang and 54.4% ± 1.9% vs 83.8% ± 1.9%, P < 0.01 with 1 g/kg Lizhong Tang; GE values: 60.7% ± 1.9% vs 66.8% ± 2.1%, P < 0.05 with 0.1 g/kg Lizhong Tang and 60.7% ± 1.9% vs 72.5% ± 1.7%, P < 0.01 with 1 g/kg Lizhong Tang). The ITRs of the GMD mice were significantly reduced compared with those of the normal mice, which were significantly and dose-dependently reversed by Lizhong Tang. Additionally, in loperamide- and cisplatin-induced models of GE delay, Lizhong Tang administration reversed the GE deficits.
CONCLUSION
These results suggest that Lizhong Tang may be a novel candidate for development as a prokinetic treatment for the GI tract.
Core tip: Lizhong Tang, a traditional Chinese medicinal formula, has been widely used in China, Japan, and South Korea for many years to ameliorate gastrointestinal (GI) disorders. Our data suggest that Lizhong Tang is a novel candidate for development as a prokinetic agent for treatment of GI motility dysfunctions in man.
