Role of NK, NKT cells and macrophages in liver transplantation

doi:10.3748/wjg.v22.i27.6135

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 22, Issue 27

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (12947)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-1) series.

Item

Count

PDF

882

WORD

472

HTML

6329

Figures (1-1)

556

Sum=8239

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

468

Download

831

Sum=1299

Publishing Process of This Article

Item

Count

Browse

1246

Download

2166

Sum=3412

Jul 21, 2016 (publication date) through Mar 3, 2026

Times Cited of This Article

Times Cited (34)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Topic Highlight

World J Gastroenterol. Jul 21, 2016; 22(27): 6135-6144
Published online Jul 21, 2016. doi: 10.3748/wjg.v22.i27.6135

Role of NK, NKT cells and macrophages in liver transplantation

René Fahrner, Felix Dondorf, Michael Ardelt, Utz Settmacher, Falk Rauchfuss

René Fahrner, Felix Dondorf, Michael Ardelt, Utz Settmacher, Falk Rauchfuss, Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, Germany

Author contributions: Fahrner R, Settmacher U and Rauchfuss F designed the review; Fahrner R, Dondorf F, Ardelt M and Rauchfuss F performed the review; Fahrner R, Settmacher U and Rauchfuss F analyzed the data; Fahrner R wrote the paper; and Dondorf F, Ardelt M, Settmacher U and Rauchfuss F revised the paper.

Conflict-of-interest statement: All authors have no conflicts of interest or financial ties to disclose.

Correspondence to: Falk Rauchfuss, MD, MSc, Department of General, Visceral and Vascular Surgery, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. falk.rauchfuss@med.uni-jena.de

Telephone: +49-3641-9322601 Fax: +49-3641-9322602

Received: March 24, 2016
Peer-review started: March 24, 2016
First decision: May 12, 2016
Revised: May 25, 2016
Accepted: June 15, 2016
Article in press: June 15, 2016
Published online: July 21, 2016
Processing time: 113 Days and 9.9 Hours

Abstract

Liver transplantation has become the treatment of choice for acute or chronic liver disease. Because the liver acts as an innate immunity-dominant organ, there are immunological differences between the liver and other organs. The specific features of hepatic natural killer (NK), NKT and Kupffer cells and their role in the mechanism of liver transplant rejection, tolerance and hepatic ischemia-reperfusion injury are discussed in this review.

Keywords: Liver transplantation; Natural killer cells; Kupffer cells; Graft rejection; Ischemia-reperfusion injury

Core tip: Liver transplantation has become the treatment of choice for acute or chronic liver disease. There are immunological differences between the liver and other organs. The specific features of selected hepatic immune cells, such as natural killer (NK), NKT and Kupffer cells, and their role in the mechanism of liver transplant rejection, tolerance and hepatic ischemia-reperfusion injury are discussed in this review.