Long-term outcomes and prognostic factors of patients with obstructive colorectal cancer: A multicenter retrospective cohort study

doi:10.3748/wjg.v22.i22.5237

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 22, Issue 22

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (9582)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-4) series, Tables (1-4) series.

Item

Count

PDF

662

WORD

344

HTML

4901

Figures (1-4)

519

Tables (1-4)

475

Sum=6901

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

954

Download

1729

Sum=2683

Jun 14, 2016 (publication date) through Feb 23, 2026

Times Cited of This Article

Times Cited (33)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Retrospective Cohort Study

World J Gastroenterol. Jun 14, 2016; 22(22): 5237-5245
Published online Jun 14, 2016. doi: 10.3748/wjg.v22.i22.5237

Long-term outcomes and prognostic factors of patients with obstructive colorectal cancer: A multicenter retrospective cohort study

Ishibe Atsushi, Ota Mitsuyoshi, Yamaguchi Kazuya, Kaida Syuhei, Kamiya Noriyuki, Momiyama Masashi, Watanabe Akira, Sekizawa Kentaro, Kamimukai Nobuyuki, Sugimasa Natsuko, Watanabe Jun, Ichikawa Yasushi, Kunisaki Chikara, Endo Itaru

Ishibe Atsushi, Endo Itaru, Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University, Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan

Ota Mitsuyoshi, Watanabe Akira, Kunisaki Chikara, Department of Surgery, Gastroenterological Center, Yokohama City University, Urafune, Minami-ku, Yokohama 232-0024, Japan

Yamaguchi Kazuya, Department of Surgery, Yokohama City Hospital, Okazawa, Hodogaya-ku, Yokohama 240-8555, Japan

Kaida Syuhei, Watanabe Jun, Department of Surgery, Yokosuka Kyosai Hospital, Maigahamadori, Yokosuka 238-8558, Japan

Kamiya Noriyuki, Department of Surgery, Ito Municipal Hospital, Ito 414-0055, Japan

Momiyama Masashi, Department of Surgery, Fujisawa City Hospital, Fujisawa 251-8550, Japan

Sekizawa Kentaro, Department of Surgery, Yokosuka City Hospital, Nagasaka, Yokosuka 240-0195, Japan

Kamimukai Nobuyuki, Department of Surgery, Yokohama Hodogaya Central Hospital, Kamadai, Hodogaya-ku, Yokohama 240-8585, Japan

Sugimasa Natsuko, Department of Surgery, Saiseikai Yokohamashi Nanbu Hospital, Kounandai, Kounan-ku, Yokohama 234-0054, Japan

Ichikawa Yasushi, Department of Oncology, Graduate School of Medicine, Yokohama City University, Yokohama 236-0004, Japan

Author contributions: Ishibe A and Ota M contributed to study conception and design; Yamaguchi K, Kaida S, Kamiya N, Momiyama M, Watanabe A, Sekizawa K, Kamimukai N, Sugimasa N, Watanabe J and Watanabe K contributed to data acquisition; Ishibe A contributed to data analysis, interpretation, and writing of article; Ichikawa Y, Kunisaki C and Endo I contributed to editing, reviewing and final approval of article.

Institutional review board statement: This study was reviewed and approved by the institutional review board of Yokohama City University.

Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.

Conflict-of-interest statement: There are no conflicts of interest to report.

Data sharing statement: No additional data are available.

Correspondence to: Atsushi Ishibe, MD, PhD, Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. aishibe@yokohama-cu.ac.jp

Telephone: +81-45-7872650 Fax: +81-45-7879161

Received: February 11, 2016
Peer-review started: February 12, 2016
First decision: March 7, 2016
Revised: March 20, 2016
Accepted: April 7, 2016
Article in press: April 7, 2016
Published online: June 14, 2016
Processing time: 112 Days and 1.9 Hours

Abstract

AIM: To investigate the long-term oncologic outcomes and prognostic factors in patients with obstructive colorectal cancer (CRC) at multiple Japanese institutions.

METHODS: We identified 362 patients diagnosed with obstructive colorectal cancer from January 1, 2002 to December 31, 2012 in Yokohama Clinical Oncology Group’s department of gastroenterological surgery. Among them, 234 patients with stage II/III disease who had undergone surgical resection of their primary lesions were analyzed, retrospectively. We report the long-term outcomes, the risk factors for recurrence, and the prognostic factors.

RESULTS: The five-year disease free survival and cancer-specific survival were 50.6% and 80.3%, respectively. A multivariate analysis showed the ASA-PS (HR = 2.23, P = 0.026), serum Albumin ≤ 4.0 g/dL (HR = 2.96, P = 0.007), T4 tumor (HR = 2.73, P = 0.002) and R1 resection (HR = 6.56, P = 0.02) to be independent risk factors for recurrence. Furthermore, poorly differentiated cancers (HR = 6.28, P = 0.009), a T4 tumor (HR = 3.46, P = 0.011) and R1 resection (HR = 6.16, P = 0.006) were independent prognostic factors in patients with obstructive CRC.

CONCLUSION: The outcomes of patients with obstructive CRC was poor. T4 tumor and R1 resection were found to be independent prognostic factors for both recurrence and survival in patients with obstructive CRC.

Keywords: Obstructive colorectal cancer; Prognostic factor; Survival

Core tip: Obstructive colorectal cancer (CRC) still have poor prognosis. However, the prognostic factor of obstructive CRC is unclear. The aim of this article is to clarify the long-term outcome and the risk factors for obstructive CRC at multiple institutions. The five-year disease free survival and cancer-specific survival were 50.6% and 80.3%, respectively. T4 tumor and R1 resection were independent prognostic factors for both recurrence and survival.