Sasaki R, Sakai Y, Tsuyuguchi T, Nishikawa T, Fujimoto T, Mikami S, Sugiyama H, Yokosuka O. Endoscopic management of unresectable malignant gastroduodenal obstruction with a nitinol uncovered metal stent: A prospective Japanese multicenter study. World J Gastroenterol 2016; 22(14): 3837-3844 [PMID: 27076769 DOI: 10.3748/wjg.v22.i14.3837]
Corresponding Author of This Article
Yuji Sakai, MD, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. sakai4754@yahoo.co.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Clinical Trials Study
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Sasaki R, Sakai Y, Tsuyuguchi T, Nishikawa T, Fujimoto T, Mikami S, Sugiyama H, Yokosuka O. Endoscopic management of unresectable malignant gastroduodenal obstruction with a nitinol uncovered metal stent: A prospective Japanese multicenter study. World J Gastroenterol 2016; 22(14): 3837-3844 [PMID: 27076769 DOI: 10.3748/wjg.v22.i14.3837]
World J Gastroenterol. Apr 14, 2016; 22(14): 3837-3844 Published online Apr 14, 2016. doi: 10.3748/wjg.v22.i14.3837
Endoscopic management of unresectable malignant gastroduodenal obstruction with a nitinol uncovered metal stent: A prospective Japanese multicenter study
Reina Sasaki, Yuji Sakai, Toshio Tsuyuguchi, Takao Nishikawa, Harutoshi Sugiyama, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
Tatsuya Fujimoto, Department of Gastroenterology, Kimitsu Chuo Hospital, Chiba 260-8670, Japan
Shigeru Mikami, Department of Gastroenterology, Kikkoman General Hospital, Chiba 260-8670, Japan
Author contributions: Sasaki R contributed to collection, organization, analysis, and interpretation of data, and drafting of the manuscript; Sakai Y contributed to conception and design of the study; Tsuyuguchi T final approvaled the manuscript; Nishikawa T critical revision of technical content; Fujimoto T, Mikami S, Sugiyama H and Yokosuka O contributed to collection and organization of data.
Institutional review board statement: This study was conducted under approval our ethical committee.
Clinical trial registration statement: Medical Information Network Clinical Trial Registry (ID: UMIN000005112).
Informed consent statement: All the treatment procedures were performed after obtaining the informed consent in writing from the patients.
Conflict-of-interest statement: The authors have no other disclosures.
Data sharing statement: I share data in the group of us.
Correspondence to: Yuji Sakai, MD, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. sakai4754@yahoo.co.jp
Telephone: +81-43-2262083 Fax: +81-43-2262088
Received: January 23, 2016 Peer-review started: January 23, 2016 First decision: February 18, 2016 Revised: February 25, 2016 Accepted: March 14, 2016 Article in press: March 14, 2016 Published online: April 14, 2016 Processing time: 66 Days and 8.6 Hours
Abstract
AIM: To determine the safety and efficacy of endoscopic duodenal stent placement in patients with malignant gastric outlet obstruction.
METHODS: This prospective, observational, multicenter study included 39 consecutive patients with malignant gastric outlet obstruction. All patients underwent endoscopic placement of a nitinol, uncovered, self-expandable metal stent. The primary outcome was clinical success at 2 wk after stent placement that was defined as improvement in the Gastric Outlet Obstruction Scoring System score relative to the baseline.
RESULTS: Technical success was achieved in all duodenal stent procedures. Procedure-related complications occurred in 4 patients (10.3%) in the form of mild pneumonitis. No other morbidities or mortalities were observed. The clinical success rate was 92.3%. The mean survival period after stent placement was 103 d. The mean period of stent patency was 149 d and the patency remained acceptable for the survival period. Stent dysfunction occurred in 3 patients (7.7%) on account of tumor growth.
CONCLUSION: Endoscopic management using duodenal stents for patients with incurable malignant gastric outlet obstruction is safe and improved patients’ quality of life.
Core tip: Endoscopic management using duodenal stents for patients with incurable malignant gastric outlet obstruction is safe and improved patients’ quality of life.
