Overexpression of Csk-binding protein decreases growth, invasion, and migration of esophageal carcinoma cells by controlling Src activation

doi:10.3748/wjg.v21.i6.1814

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Feb 14, 2015 (publication date) through Mar 3, 2026

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Feb 14, 2015; 21(6): 1814-1820
Published online Feb 14, 2015. doi: 10.3748/wjg.v21.i6.1814

Overexpression of Csk-binding protein decreases growth, invasion, and migration of esophageal carcinoma cells by controlling Src activation

Dong Zhou, Peng Dong, Yu-Min Li, Fa-Cai Guo, An-Ping Zhang, Run-Ze Song, Ya-Min Zhang, Zhi-Yong Li, Dong Yuan, Chuan Yang

Dong Zhou, Yu-Min Li, Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China

Peng Dong, Department of Cardiology, Aviation General Hospital, Beijing 100012, China

Fa-Cai Guo, An-Ping Zhang, Run-Ze Song, Ya-Min Zhang, Zhi-Yong Li, Dong Yuan, Chuan Yang, Department of Vascular Surgery, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China

Author contributions: Zhou D and Dong P contributed to the work equally and should be regarded as co-first authors; Zhou D and Li YM designed the research; Zhou D, Dong P, Guo FC and Zhang AP performed the research; Zhang YM, Li ZY, Yuan D and Yang C analyzed data; Zhou D and Dong P wrote the paper.

Supported by Gansu Provincial Natural Science Foundation, No. 1308RJZA188; and the Fundamental Research Funds for the Central Universities, No. lzujbky-2011-T03-16.

Correspondence to: Yu-Min Li, PhD, Professor, Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, 82 Cuiyingmen, Lanzhou 730030, Gansu Province, China. 13919951166@139.com

Telephone: +86-931-8942935

Received: May 24, 2014
Peer-review started: May 24, 2014
First decision: July 15, 2014
Revised: October 20, 2014
Accepted: December 19, 2014
Article in press: December 22, 2014
Published online: February 14, 2015
Processing time: 263 Days and 6.7 Hours

Abstract

AIM: To investigate the mechanisms by which Csk-binding protein (CBP) inhibits tumor progression in esophageal carcinoma.

METHODS: A CBP overexpressing esophageal carcinoma cell line (TE-1) was established. The growth, invasion, and migration of CBP-TE-1 cells, as well as the expression of Src were then determined and compared with those in normal TE-1 cells.

RESULTS: The expression of Src was decreased by the overexpression of CBP in TE-1 cells. The growth, invasion, and migration of TE-1 cells were decreased by the overexpression of CBP.

CONCLUSION: This study indicates that CBP may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src. CBP may be a potential tumor suppressor and targeting the CBP gene may be an alternative strategy for the development of therapies for esophageal carcinoma.

Keywords: Csk-binding protein; Esophageal carcinoma; Cell growth; Invasion; Migration

Core tip: Csk-binding protein (CBP) is a ubiquitously expressed transmembrane protein and functions as a suppressor of Src-mediated tumor progression by promoting the inactivation of Src. Here, we established a CBP overexpressing esophageal carcinoma cell line (TE-1) and found that the overexpression of CBP significantly decreased the proliferation, invasion, and migration of TE-1 cells, accompanied by decreased activation of Src. These results indicate that CBP may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src. Targeting the CBP gene may be an alternative strategy for the development of therapies for esophageal carcinoma.