Unfavorable outcome of antiviral therapy in cytomegalovirus-positive ulcerative colitis may be due to inappropriate study inclusion in meta-analysis

doi:10.3748/wjg.v21.i5.1689

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Feb 7, 2015 (publication date) through Mar 1, 2026

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World Journal of Gastroenterology

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1007-9327

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Letter to the Editor

World J Gastroenterol. Feb 7, 2015; 21(5): 1689-1690
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1689

Unfavorable outcome of antiviral therapy in cytomegalovirus-positive ulcerative colitis may be due to inappropriate study inclusion in meta-analysis

Xiao-Wei Wu, Miao-Fang Yang, Nan Li, Fang-Yu Wang

Xiao-Wei Wu, Miao-Fang Yang, Nan Li, Fang-Yu Wang, Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China

Author contributions: Wu XW, Li N and Wang FY contributed to primary concept and data analysis; Wu XW and Yang MF contributed to writing the manuscript.

Correspondence to: Fang-Yu Wang, PhD, Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University, No. 305 Zhongshan East Road, Nanjing 210002, Jiangsu Province, China. wangfangyu2014@126.com

Telephone: +86-25-80860051 Fax: +86-25-80860151

Received: September 9, 2014
Peer-review started: September 10, 2014
First decision: October 14, 2014
Revised: November 13, 2014
Accepted: December 16, 2014
Article in press: December 16, 2014
Published online: February 7, 2015
Processing time: 152 Days and 19.4 Hours

Abstract

Some previous articles reported that antiviral treatment was effective to reduce the colectomy rate in ulcerative colitis (UC) patients with cytomegalovirus (CMV) infection. Kopylov et al recently carried out a systematic review and meta-analysis to evaluate the impact of antiviral therapy on CMV-positive UC. The results showed that patients who received antiviral treatment had a higher risk of 30-d colectomy. We found that in this meta-analysis, some studies were inappropriately included, leading to an unfavorable outcome of anti-CMV therapy in UC patients.

Keywords: Ulcerative colitis; Cytomegalovirus; Antiviral therapy; Colectomy; Meta-analysis

Core tip: A recently article in the World Journal of Gastroenterology entitled “Antiviral therapy in cytomegalovirus-positive ulcerative colitis: A systematic review and meta-analysis” showed that antiviral therapy caused a higher risk of 30-d colectomy in cytomegalovirus-positive ulcerative colitis patients. We found that in this article, unfavorable outcome of antiviral therapy was due to inappropriate study inclusion in meta-analysis.