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Fahrner R, Dondorf F, Ardelt M, Dittmar Y, Settmacher U, Rauchfuß F. Liver transplantation for hepatocellular carcinoma - factors influencing outcome and disease-free survival. World J Gastroenterol 2015; 21(42): 12071-12082 [PMID: 26576092 DOI: 10.3748/wjg.v21.i42.12071]
World J Gastroenterol. Nov 14, 2015; 21(42): 12071-12082 Published online Nov 14, 2015. doi: 10.3748/wjg.v21.i42.12071
Liver transplantation for hepatocellular carcinoma - factors influencing outcome and disease-free survival
René Fahrner, Felix Dondorf, Michael Ardelt, Yves Dittmar, Utz Settmacher, Falk Rauchfuß
René Fahrner, Felix Dondorf, Michael Ardelt, Yves Dittmar, Utz Settmacher, Falk Rauchfuß, Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07740 Jena, Germany
Author contributions: Fahrner R, Settmacher U and Rauchfuß F designed the review; Fahrner R, Dondorf F, Ardelt M, Dittmar Y and Rauchfuß F performed the review; Fahrner R, Settmacher U and Rauchfuß F analyzed the data; Fahrner R and Rauchfuß F wrote the paper; Dondorf F, Ardelt M, Dittmar Y and Settmacher U revised the paper.
Conflict-of-interest statement: All authors have no conflicts of interest or financial ties to disclose.
Correspondence to: Falk Rauchfuß, MD, MSc, Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07740 Jena, Germany. falk.rauchfuss@med.uni-jena.de
Telephone: +49-3641-9322601 Fax: +49-3641-9322602
Received: April 28, 2015 Peer-review started: May 5, 2015 First decision: July 13, 2015 Revised: August 4, 2015 Accepted: September 14, 2015 Article in press: September 14, 2015 Published online: November 14, 2015 Processing time: 197 Days and 10.6 Hours
Abstract
Hepatocellular carcinoma is one of the leading causes of cancer-related death worldwide. Liver transplantation can be a curative treatment in selected patients. However, there are several factors that influence disease-free survival after transplantation. This review addresses the pre-, intra- and postoperative factors that influence the risk of tumor recurrence after liver transplantation.
Core tip: Hepatocellular carcinoma is one of the leading causes of cancer-related death worldwide. Liver transplantation can be a curative treatment in selected patients. This review addresses the pre-, intra-, and postoperative factors that influence disease-free survival and the risk of tumor recurrence after liver transplantation. Furthermore, novel diagnostic methods are presented and discussed.
