Retrospective Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 28, 2015; 21(4): 1216-1221
Published online Jan 28, 2015. doi: 10.3748/wjg.v21.i4.1216
Preoperative CA 125 is significant indicator of curative resection in gastric cancer patients
Dae Hoon Kim, Hyo Yung Yun, Dong Hee Ryu, Hye-Suk Han, Joung-Ho Han, Soon Man Yoon, Sei Jin Youn
Dae Hoon Kim, Hyo Yung Yun, Dong Hee Ryu, Department of Surgery, Chungbuk National University College of Medicine, Cheongju 361-763, South Korea
Hye-Suk Han, Joung-Ho Han, Soon Man Yoon, Sei Jin Youn, Internal Medicine, Chungbuk National University College of Medicine, Cheongju 361-763, South Korea
Author contributions: Yun HY designed the study; Kim DH and Yun HY wrote the manuscript; Kim DH and Ryu DH provided the collection of data; Han HS, Han JH, Yoon SM and Youn SJ involved in editing the manuscript.
Supported by Research grant of Chungbuk National University in 2013.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hyo Yung Yun, MD, PhD, Department of Surgery, Chungbuk National University College of Medicine, 410 Sungbong-ro, Heungduk-gu, Cheongju 361-763, South Korea. unhyo@chungbuk.ac.kr
Telephone: +82-43-2696032 Fax: +82-43-2666037
Received: June 27, 2014
Peer-review started: June 28, 2014
First decision: August 6, 2014
Revised: August 20, 2014
Accepted: September 29, 2014
Article in press: September 30, 2014
Published online: January 28, 2015
Processing time: 214 Days and 4.7 Hours
Abstract

AIM: To investigate the correlation among tumor markers, curative resection, and recurrence in gastric cancer.

METHODS: The patients with preoperative tumor makers [Carcinoembryonic antigen, Carbohydrate antigen (CA) 19-9, and CA 125] and elective gastrectomy between January 2000 and December 2009 at Chungbuk National University Hospital were enrolled in this study. We analyzed the relationship among the tumor makers, curative resection and recurrence, retrospectively.

RESULTS: Among the 679 patients with gastric cancer, curative resection was 93.6% (n = 636) and non-curative resection was 6.4% (n = 43). The independent risk factors for the non-curative resection were tumor location and the positivity of preoperative serum CA 19-9 and CA 125 levels. After curative resection, the independent prognostic risk factors for recurrence in curative resection were gender, stage, and preoperative increased serum CA 125 level (HR = 2.431, P =0.020), in a multivariate analysis.

CONCLUSION: Preoperative CA 125 is a useful predictive biomarker for curative resection and prognostic biomarker for recurrence in gastric cancer patients.

Keywords: Gastric Cancer; Tumor Marker; Carcinoembryonic antigen; Carbohydrate antigen 19-9; Carbohydrate antigen 125

Core tip: Tumor marker such as carcinoembryonic antigen, Carbohydrate antigen (CA) 19-9, and CA 125 in gastric cancer are usual tools for predicting prognosis or monitoring. The aim of this study was to investigate the correlation among tumor markers, curative resection, and recurrence in gastric cancer. Our data showed that preoperative CA 19-9 and CA 125 are independent risk factor of non-curative operation. And preoperative CA 125 is independent risk factor for recurrence after curative operation. Preoperative CA 125 is considered useful marker for predicting curative operation and prediction of recurrence after curative resection in gastric cancer patients.