Published online Jul 14, 2015. doi: 10.3748/wjg.v21.i26.7970
Peer-review started: January 30, 2015
First decision: March 10, 2015
Revised: March 27, 2015
Accepted: May 2, 2015
Article in press: May 4, 2015
Published online: July 14, 2015
Processing time: 165 Days and 5.2 Hours
Ampullary neoplasms, although rare, present distinctive clinical and pathological features from other neoplastic lesions of the periampullary region. No specific guidelines about their management are available, and they are often assimilated either to biliary tract or to pancreatic carcinomas. Due to their location, they tend to become symptomatic at an earlier stage compared to pancreatic malignancies. This behaviour results in a higher resectability rate at diagnosis. From a pathological point of view they arise in a zone of transition between two different epithelia, and, according to their origin, may be divided into pancreatobiliary or intestinal type. This classification has a substantial impact on prognosis. In most cases, pancreaticoduodenectomy represents the treatment of choice when there is an overt or highly suspicious malignant behaviour. The rate of potentially curative resection is as high as 90% and in high-volume centres an acceptable rate of complications is reported. In selected situations less invasive approaches, such as ampullectomy, have been advocated, although there are some concerns mainly because of a higher recurrence rate associated with limited resections for invasive carcinomas. Importantly, these methods have the drawback of not including an appropriate lymphadenectomy, while nodal involvement has been shown to be frequently present also in apparently low-risk carcinomas. Endoscopic ampullectomy is now the procedure of choice in case of low up to high-grade dysplasia providing a proper assessment of the T status by endoscopic ultrasound. In the present paper the evidence currently available is reviewed, with the aim of offering an updated framework for diagnosis and management of this specific type of disease.
Core tip: In this paper we review current evidence regarding ampullary neoplasm, with a particular focus on diagnosis and treatment. We are providing a framework for management of these neoplasms that, although rare, display distinctive clinical features. Current evidence about optimal management is reviewed, outlining the role of surgery as compared to newer endoscopic techniques: indeed, while surgery is mandatory for invasive carcinomas due to possible nodal involvement, endoscopy should be considered for non-invasive lesions.