Kong DR, Wang JG, Sun B, Wang MQ, Chen C, Yu FF, Xu JM. β-2 Adrenergic receptor gene polymorphism and response to propranolol in cirrhosis. World J Gastroenterol 2015; 21(23): 7191-7196 [PMID: 26109805 DOI: 10.3748/wjg.v21.i23.7191]
Corresponding Author of This Article
De-Run Kong, MD, Professor, Department of Gastroenterology, the first Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui Province, China. kongderun@ahmu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
De-Run Kong, Jin-Guang Wang, Bin Sun, Chen Chen, Fang-Fang Yu, Jian-Ming Xu, Department of Gastroenterology, the first Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Ming-Quan Wang, Department of Radiology, the first Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Author contributions: Kong DR, Wang JG, Sun B and Wang MQ contributed equally to this work; Wang JG and Kong DR performed the majority of experiments and analyzed the data; Sun B and Wang MQ performed the molecular investigations; Chen C and Yu FF participated equally in treatment of patients; Kong DR and Xu JM designed and coordinated the research; Kong DR and Wang JG wrote the paper.
Supported by National Natural Science Foundation of China, No. 81271736.
Ethics approval: This study was approval from the Ethics Committee of Anhui Medical University.
Conflict-of-interest: We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work.
Data sharing: Technical appendix, statistical code, and dataset could be available from the corresponding author at kdr168@sohu.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: De-Run Kong, MD, Professor, Department of Gastroenterology, the first Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui Province, China. kongderun@ahmu.edu.cn
Telephone: +86-551-62922105 Fax: +86-551-65120742
Received: October 27, 2014 Peer-review started: October 28, 2014 First decision: December 26, 2014 Revised: January 26, 2015 Accepted: February 11, 2015 Article in press: February 11, 2015 Published online: June 21, 2015 Processing time: 235 Days and 19.6 Hours
Abstract
AIM: To evaluate the association of β-2 adrenergic receptor (β2-AR) gene polymorphism with response of variceal pressure to propranolol in cirrhosis.
METHODS: Sixty-four non-related cirrhotic patients participated in this study and accepted variceal pressure measurement before and after propranolol administration. Polymorphism of the β2-AR gene was determined by directly sequencing of the polymerase chain reaction products from the DNA samples that were prepared from the patients.
RESULTS: The prevalence of Gly16-Glu/Gln27 and Arg16-Gln27 homozygotes, and compound heterozygotes was 29.7%, 10.9%, and 59.4%, respectively. Patients with cirrhosis with Gly16-Glu/Gln27 homozygotes had a greater decrease of variceal pressure after propranolol administration than those with Arg16-Gln27 homozygotes or with compound heterozygotes (22.4% ± 2.1%, 13.1% ± 2.7% and 12.5% ± 3.1%, respectively, P < 0.01).
CONCLUSION: The variceal pressure response to propranolol was associated with polymorphism of β2-AR gene. Patients with the Gly16-Glu/Gln27 homozygotes probably benefit from propranolol therapy.
Core tip: The study explored the influence of β-2 adrenergic receptor (β2-AR) polymorphism and the response of esophageal variceal pressure to chronic treatment with propranolol. The originality was that we associated the polymorphism to the measurement of variceal pressure and considered the response to propranolol administration. We found that the variceal pressure response to propranolol was associated with β2-AR gene polymorphisms, and that the patients with the Gly16-Glu/Gln27 homozygotes seem to benefit more from propranolol therapy.
