Retrospective Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2015; 21(18): 5542-5547
Published online May 14, 2015. doi: 10.3748/wjg.v21.i18.5542
Comparison of the diagnostic yield and outcomes between standard 8 h capsule endoscopy and the new 12 h capsule endoscopy for investigating small bowel pathology
Merajur Rahman, Stuart Akerman, Bethany DeVito, Larry Miller, Meredith Akerman, Keith Sultan
Merajur Rahman, Bethany DeVito, Larry Miller, Keith Sultan, Division of Gastroenterology, Department of Medicine, North Shore-Long Island Jewish Medical Center, Manhasset, NY 11030, United States
Stuart Akerman, NSLIJ Western Suffolk Gastroenterology, Bay Shore, NY 11706, United States
Meredith Akerman, Feinstein Institute for Medical Research, Manhasset, NY 11706, United States
Author contributions: Rahman M study concept and design, data collection, data analysis, drafting and revising the article; Akerman S study concept and design, drafting and revising the article; DeVito B study concept and design, drafting and revising the article; Miller L study concept and design, drafting and revising the article; Akerman M contributed to data analysis; Sultan K study concept and design, data collection, data analysis, drafting and revising the article.
Ethics approval: The study was reviewed and approved by the North Shore-Long Island Jewish Institutional Review Board.
Informed consent: Waiver of informed consent was requested and granted by the North Shore-Long Island Jewish Institutional Review board because information recorded by the investigators in such a manner that the subjects cannot be identified, directly or through identifiers linked to the subjects.
Conflict-of-interest: All authors have no financial relationships to disclose.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Merajur Rahman, MD, Division of Gastroenterology, Department of Medicine, North Shore-Long Island Jewish Medical Center, 300 Community Drive, Manhasset, NY 11030, United States. rmerajur@nshs.edu
Telephone: +1-516-5624286 Fax: +1-516-5623555
Received: November 5, 2014
Peer-review started: November 7, 2014
First decision: November 26, 2014
Revised: December 10, 2014
Accepted: January 8, 2015
Article in press: January 8, 2015
Published online: May 14, 2015
Processing time: 194 Days and 5.8 Hours
Abstract

AIM: To evaluate the completion rate and diagnostic yield of the PillCam SB2-ex in comparison to the PillCam SB2.

METHODS: Two hundred cases using the 8-h PillCam SB2 were retrospectively compared to 200 cases using the 12 h PillCam SB2-ex at a tertiary academic center. Endoscopically placed capsules were excluded from the study. Demographic information, indications for capsule endoscopy, capsule type, study length, completion of exam, clinically significant findings, timestamp of most distant finding, and significant findings beyond 8 h were recorded.

RESULTS: The 8 and 12 h capsule groups were well matched respectively for both age (70.90 ± 14.19 vs 71.93 ± 13.80, P = 0.46) and gender (45.5% vs 48% male, P = 0.69). The most common indications for the procedure in both groups were anemia and obscure gastrointestinal bleeding. PillCam SB2-ex had a significantly higher completion rate than PillCam SB2 (88% vs 79.5%, P = 0.03). Overall, the diagnostic yield was greater for the 8 h capsule (48.5% for SB2 vs 35% for SB2-ex, P = 0.01). In 4/70 (5.7%) of abnormal SB2-ex exams the clinically significant finding was noted in the small bowel beyond the 8 h mark.

CONCLUSION: In our study, we found the PillCam SB2-ex to have a significantly increased completion rate, though without any improvement in diagnostic yield compared to the PillCam SB2.

Keywords: PillCam SB2; Capsule endoscopy; Obscure gastrointestinal bleeding

Core tip: The PillCam SB2-ex and the PillCam SB2 have the same size and specifications, except the PillCam SB2-ec offers 12 h of operation, 4 more hours than the original PillCam SB2. There has been no evaluation regarding the completion rate and diagnostic yield between these two capsules. We examined 200 cases using the 8-h PillCam SB2 and compared it to 200 cases using the 12 h PillCam SB2-ex. We found the PillCam SB2-ex to have a significantly increased completion rate, though without any improvement in the diagnostic yield compared to the PillCam SB2.